{"id":"W2946307060","doi":"10.1093/jnci/djz075","title":"Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy","year":2019,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Effects of Radiation Exposure","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; Medical Research Council; Manchester Biomedical Research Centre; National Cancer Institute; Cancer Research UK; National Institutes of Health; European Commission; National Institute for Health and Care Research; National Heart, Lung, and Blood Institute; U.S. Department of Defense","keywords":"Prostate cancer; Single-nucleotide polymorphism; Radiogenomics; Urinary system; Oncology; Medicine; Internal medicine; Cancer; Biology; Genetics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001575135,0.0001911495,0.001115651,0.0004667833,0.00006344534,0.00002892687,0.0002586397,0.00009678343,0.0007030287],"category_scores_gemma":[0.0004238724,0.0001249565,0.00113271,0.0008762506,0.00005387978,0.0003529608,0.0000291324,0.0003467455,0.000002832959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001964628,"about_ca_system_score_gemma":0.001036013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001237066,"about_ca_topic_score_gemma":0.0003151967,"domain_scores_codex":[0.9969844,0.0001973759,0.000894031,0.0001969822,0.001544169,0.0001831056],"domain_scores_gemma":[0.9958769,0.0002824886,0.001818092,0.0002119625,0.001715578,0.00009494415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006269064,0.0002259313,0.722789,0.00003287111,0.109232,0.000005239628,0.0008022335,0.1619329,0.003565051,0.00001362232,0.0007207075,0.00005360287],"study_design_scores_gemma":[0.002811599,0.0002812311,0.9173321,0.00001694475,0.06795757,0.000005771742,0.00002900714,0.0008971301,0.001334572,0.00003321774,0.009138781,0.0001621118],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872239,0.004277944,0.00003562775,0.006095173,0.001065663,0.0008813922,0.0002863773,0.000007242807,0.0001266317],"genre_scores_gemma":[0.9932991,0.0004556444,0.0002922105,0.003434143,0.0003736934,0.00003797633,0.000006832915,0.00001990654,0.002080488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1945431,"threshold_uncertainty_score":0.7697671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03476226152163881,"score_gpt":0.3322929284243723,"score_spread":0.2975306669027335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}