{"id":"W2946368559","doi":"10.1089/ars.2018.7648","title":"Reactive Oxygen Species-Dependent Calpain Activation Contributes to Airway and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease","year":2019,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; U.S. Department of Veterans Affairs","keywords":"Calpain; COPD; Pulmonary artery; Medicine; Lung; Airway resistance; Cardiology; Pathology; Internal medicine; Chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000346005,0.0001886006,0.0001961861,0.0001387066,0.0001343736,0.00004358974,0.00006237914,0.0001426497,0.00001573792],"category_scores_gemma":[0.00006603365,0.0001731621,0.00006370352,0.0001409129,0.00005145345,0.00002732506,0.0001015842,0.0001258732,0.000003167591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008813356,"about_ca_system_score_gemma":0.00008099961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006014073,"about_ca_topic_score_gemma":0.000008950312,"domain_scores_codex":[0.9986856,0.000102689,0.0002531199,0.0005526736,0.0001616023,0.0002442978],"domain_scores_gemma":[0.9994747,0.00002883091,0.00008544955,0.0001986737,0.00008477282,0.000127589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003373098,0.00003907604,0.01174252,0.00005681514,0.00004185411,0.000008103243,0.0000400331,0.003420897,0.9801499,0.0001126626,0.000009486836,0.004041369],"study_design_scores_gemma":[0.001675887,0.0002228142,0.4996477,0.0006318989,0.00007127058,0.00002778302,0.001024052,0.02605948,0.4624453,0.001051326,0.006342367,0.0008001425],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917984,0.001814021,0.005142203,0.0002332384,0.000124477,0.0006528795,0.00001410485,0.0000147019,0.0002059604],"genre_scores_gemma":[0.9984366,0.0002593104,0.0001114149,0.000137874,0.0001909974,0.00002363686,0.0001094991,0.00002316964,0.0007075337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5177046,"threshold_uncertainty_score":0.7061344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006450209719621563,"score_gpt":0.2154194489744642,"score_spread":0.2089692392548426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}