{"id":"W2946386783","doi":"10.1016/s1470-2045(19)30167-6","title":"Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multicentre, randomised, open-label, phase 3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1681,"is_retracted":false,"has_abstract":false,"ca_institutions":"William Osler Health System","funders":"F. Hoffmann-La Roche","keywords":"Carboplatin; Medicine; Paclitaxel; Atezolizumab; Chemotherapy; Oncology; Nab-paclitaxel; Open label; Internal medicine; Lung cancer; Cisplatin; Cancer; Randomized controlled trial; Nivolumab; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001436069,0.001654114,0.003255459,0.0004323825,0.0002972732,0.001330272,0.001050701,0.001718516,0.005388233],"category_scores_gemma":[0.001600775,0.0006528576,0.002665903,0.0004110274,0.001095064,0.001309871,0.0005818301,0.004262108,0.001004379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008365454,"about_ca_system_score_gemma":0.0008349705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001128154,"about_ca_topic_score_gemma":0.002456475,"domain_scores_codex":[0.999467,0.0002713145,0.00002721836,0.0001078579,0.00004012597,0.00008655836],"domain_scores_gemma":[0.9993384,0.0002209096,0.0001440123,0.00004824136,0.00003468196,0.0002136695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9768663,0.003732312,0.0004754365,0.0005931242,0.001077492,0.0000234917,0.00005103008,0.0003888814,0.001942782,0.0001040249,0.0008094474,0.01393559],"study_design_scores_gemma":[0.9091512,0.0872168,0.001623417,0.00003647053,0.0005854188,0.00003762478,0.00002580048,0.0004491236,0.000259013,0.0001356174,0.0004628479,0.00001657619],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893066,0.004456061,0.0004360082,0.0007439046,0.000680422,0.00139186,0.0009042886,0.0001335074,0.001947351],"genre_scores_gemma":[0.989004,0.002355227,0.001054181,0.0009492929,0.0004053717,0.001457063,0.001224642,0.00003598972,0.003514351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005388233,"threshold_uncertainty_score":0.0180254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04848363890646765,"score_gpt":0.3745263839184664,"score_spread":0.3260427450119987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}