{"id":"W2946423464","doi":"10.1007/s00415-019-09363-4","title":"An update on genetic frontotemporal dementia","year":2019,"lang":"en","type":"review","venue":"Journal of Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":513,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Institute for Health and Care Research","keywords":"C9orf72; Frontotemporal dementia; Genetic testing; Amyotrophic lateral sclerosis; Medicine; Genetics; Psychology; Psychiatry; Dementia; Disease; Pathology; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00117816,0.0009220559,0.001637539,0.00274676,0.0004400336,0.001566436,0.001278099,0.002496185,0.01377234],"category_scores_gemma":[0.003201736,0.0003408969,0.0008824125,0.001755709,0.0005115182,0.002609601,0.001023309,0.003575721,0.006266463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001148089,"about_ca_system_score_gemma":0.001516096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00222285,"about_ca_topic_score_gemma":0.004973378,"domain_scores_codex":[0.9994823,0.0001074849,0.0001143954,0.00007723627,0.0001650078,0.0000535727],"domain_scores_gemma":[0.998314,0.0007967728,0.000117847,0.00004521364,0.0005567128,0.0001694156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001051145,0.00004305008,0.0005289671,0.005088795,0.0001067295,0.0009667409,0.0001216642,0.0001415063,0.0005514469,0.002326321,0.3319369,0.6580827],"study_design_scores_gemma":[0.00002778038,0.00004027276,0.000570773,0.003623426,0.00009958,0.002593741,0.00005756063,0.00003793816,0.00007999379,0.00126659,0.9915878,0.00001452536],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003910093,0.9678826,0.0005690417,0.01209877,0.01099518,0.00002167032,0.0003403513,0.0001061076,0.007595167],"genre_scores_gemma":[0.001684535,0.9638404,0.001127705,0.01290174,0.01373235,0.00004838365,0.000931013,0.00003438802,0.005699514],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01377234,"threshold_uncertainty_score":0.04607308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1125983132052786,"score_gpt":0.4141635332659411,"score_spread":0.3015652200606625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}