{"id":"W2946426003","doi":"10.3389/fnbeh.2019.00111","title":"Heritable Differences in Catecholamine Signaling Modulate Susceptibility to Trauma and Response to Methylphenidate Treatment: Relevance for PTSD","year":2019,"lang":"en","type":"article","venue":"Frontiers in Behavioral Neuroscience","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Alcohol Abuse and Alcoholism; Center of Excellence for Stress and Mental Health; Fonds de Recherche du Québec - Santé; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Methylphenidate; Catecholamine; Relevance (law); Neuroscience; Psychology; Medicine; Clinical psychology; Psychiatry; Attention deficit hyperactivity disorder","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003022276,0.00030742,0.0004694113,0.0004463397,0.0001437058,0.0001684764,0.0005628291,0.00007968154,0.000007436185],"category_scores_gemma":[0.000535093,0.0002828072,0.00006420043,0.001235106,0.0001536995,0.0004388777,0.0001436785,0.0001625023,0.000005678151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002465085,"about_ca_system_score_gemma":0.00006600643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002968948,"about_ca_topic_score_gemma":0.000195155,"domain_scores_codex":[0.9967341,0.0002647339,0.0004365895,0.001447785,0.0003403772,0.0007764348],"domain_scores_gemma":[0.9988891,0.0002262203,0.00008646317,0.0005208266,0.00002931823,0.0002480163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001972513,0.0002065529,0.1631403,0.000008660703,2.222401e-7,0.00003349357,0.0007396042,0.0006236873,0.8124876,0.000007526561,0.00001131169,0.02076854],"study_design_scores_gemma":[0.001613301,0.00350678,0.5844952,0.00007802433,0.000008963225,0.000009775744,0.0004160025,0.006079171,0.4023305,0.0001557314,0.0007832875,0.0005231855],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949036,0.00006272872,0.00185399,0.000377366,0.0008333336,0.001805731,0.000103381,0.00005223036,0.000007605735],"genre_scores_gemma":[0.9941784,0.00006852124,0.004081273,0.0003592615,0.00001061037,0.0002740124,7.883368e-7,0.00002690656,0.001000206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4213549,"threshold_uncertainty_score":0.9999624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0611402233797753,"score_gpt":0.3213881831096162,"score_spread":0.2602479597298409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}