{"id":"W2946428704","doi":"10.21873/anticanres.13355","title":"Lapatinib Inhibits Amphiregulin-induced BeWo Choriocarcinoma Cell Proliferation by Reducing ERK1/2 and AKT Signaling Pathways","year":2019,"lang":"en","type":"article","venue":"Anticancer Research","topic":"Gestational Trophoblastic Disease Studies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Amphiregulin; Lapatinib; Cancer research; Protein kinase B; Choriocarcinoma; PI3K/AKT/mTOR pathway; Cell growth; Signal transduction; Epidermal growth factor receptor; Epidermal growth factor; Biology; Chemistry; Cell biology; Internal medicine; Cancer; Receptor; Medicine; Trastuzumab; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009093627,0.0002745476,0.0001827088,0.0002363973,0.0001126106,0.0001248504,0.00009682911,0.0001321124,0.001582516],"category_scores_gemma":[0.0001108739,0.00006454282,0.0001415055,0.0001200925,0.0001047931,0.000121855,0.0001081519,0.0004184866,0.0001452184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001804941,"about_ca_system_score_gemma":0.0001904309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004095149,"about_ca_topic_score_gemma":0.0008034093,"domain_scores_codex":[0.9999384,0.00001170218,0.000005909487,0.000006629258,0.00001603868,0.00002127911],"domain_scores_gemma":[0.9999653,0.000005569156,0.000009689807,0.000002871966,0.000005291666,0.00001135101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009886337,0.0003475094,0.0007553465,0.0002005078,0.00002186956,0.0001392843,0.00001883638,0.0001403309,0.98485,0.000137111,0.0003654103,0.0120351],"study_design_scores_gemma":[0.0003751775,0.002727033,0.01822018,0.00002673499,0.00005091834,0.0008698931,0.00004648201,0.001638971,0.9670008,0.00009716828,0.008939107,0.000007433923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886467,0.006490189,0.0009397239,0.0001671884,0.00004000894,0.00006522812,0.0002025644,0.00006546611,0.003383087],"genre_scores_gemma":[0.9934735,0.002983019,0.001101529,0.00007498944,0.00001496517,0.00008050949,0.0004408492,0.000008307713,0.001822372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001582516,"threshold_uncertainty_score":0.005294025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05745718348208072,"score_gpt":0.3430821587730327,"score_spread":0.285624975290952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}