{"id":"W2946428704","doi":"10.21873/anticanres.13355","title":"Lapatinib Inhibits Amphiregulin-induced BeWo Choriocarcinoma Cell Proliferation by Reducing ERK1/2 and AKT Signaling Pathways","year":2019,"lang":"en","type":"article","venue":"Anticancer Research","topic":"Gestational Trophoblastic Disease Studies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Amphiregulin; Lapatinib; Cancer research; Protein kinase B; Choriocarcinoma; PI3K/AKT/mTOR pathway; Cell growth; Signal transduction; Epidermal growth factor receptor; Epidermal growth factor; Biology; Chemistry; Cell biology; Internal medicine; Cancer; Receptor; Medicine; Trastuzumab; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006579481,0.0001780901,0.00030944,0.0002056494,0.0002458268,0.00008006154,0.0000899069,0.00007959634,0.00019772],"category_scores_gemma":[0.0003973909,0.000159485,0.00004638752,0.0004390984,0.0001550138,0.000139331,0.0001242415,0.0004260433,0.0001827594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001361991,"about_ca_system_score_gemma":0.0004752805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002046724,"about_ca_topic_score_gemma":0.000007234346,"domain_scores_codex":[0.9973266,0.0001282246,0.0003066406,0.0005710447,0.001123317,0.0005442277],"domain_scores_gemma":[0.9983818,0.0003891363,0.00006264083,0.0002871786,0.0006326501,0.0002465768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005729112,0.0003028099,0.06664094,0.0006774403,0.00009840386,0.00003264203,0.001880949,0.00001611124,0.9213632,0.0008892253,0.003198233,0.004327168],"study_design_scores_gemma":[0.006694193,0.002831985,0.1328983,0.001268505,0.0001623564,0.0000267733,0.003367431,0.003261817,0.8466164,0.0009728207,0.001273975,0.0006254653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916534,0.0007098368,0.00002254817,0.001233352,0.00009711832,0.001094139,0.00002815132,0.00004303012,0.005118364],"genre_scores_gemma":[0.9976878,0.0001054121,0.0003985744,0.0001385596,0.0002462704,0.00010985,0.00004989933,0.0000406073,0.001222998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07474678,"threshold_uncertainty_score":0.6503611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05745718348208072,"score_gpt":0.3430821587730327,"score_spread":0.285624975290952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}