{"id":"W2946458937","doi":"10.1021/acs.jproteome.9b00173","title":"Therapy-Induced MHC I Ligands Shape Neo-Antitumor CD8 T Cell Responses during Oncolytic Virus-Based Cancer Immunotherapy","year":2019,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Dalhousie Medical Research Foundation","keywords":"Oncolytic virus; MHC class I; Immunotherapy; Cancer immunotherapy; CD8; Major histocompatibility complex; Biology; Antigen; Cancer research; Cytotoxic T cell; Antigen presentation; Antigen processing; MHC restriction; Tumor antigen; Immunology; T cell; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004463903,0.0003315642,0.0005082724,0.0007794971,0.0002524368,0.000183235,0.001201679,0.0002945038,0.0007567747],"category_scores_gemma":[0.0001928852,0.0002715124,0.0003688065,0.0007351008,0.0001853965,0.00003202561,0.0001679089,0.001261937,0.00008707016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000270434,"about_ca_system_score_gemma":0.002684645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007646222,"about_ca_topic_score_gemma":0.0000459832,"domain_scores_codex":[0.9951467,0.0008485976,0.0007152975,0.0005240577,0.001726346,0.001039008],"domain_scores_gemma":[0.9969968,0.0001554282,0.0003634331,0.0008676237,0.001295562,0.0003211065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03681771,0.0003705767,0.002320584,0.0001001849,0.0001763798,0.00007632089,0.0001059088,0.0001312678,0.9556721,8.868336e-7,0.000209141,0.004018867],"study_design_scores_gemma":[0.005534043,0.01321867,0.00214087,0.0001469938,0.000005978431,0.00003879665,0.00008757141,0.0001514595,0.9730996,0.00002281499,0.005249208,0.0003039866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990845,0.006489225,0.00001173939,0.0008807122,0.0001962641,0.001335104,0.00001681418,0.00001757327,0.0002076216],"genre_scores_gemma":[0.9920222,0.004245852,0.0001637942,0.0001737984,0.000741593,0.0001308984,0.000004442406,0.000157392,0.002360101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03128367,"threshold_uncertainty_score":0.9999737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05558056950259602,"score_gpt":0.3865183049597913,"score_spread":0.3309377354571953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}