{"id":"W2946458937","doi":"10.1021/acs.jproteome.9b00173","title":"Therapy-Induced MHC I Ligands Shape Neo-Antitumor CD8 T Cell Responses during Oncolytic Virus-Based Cancer Immunotherapy","year":2019,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Dalhousie Medical Research Foundation","keywords":"Oncolytic virus; MHC class I; Immunotherapy; Cancer immunotherapy; CD8; Major histocompatibility complex; Biology; Antigen; Cancer research; Cytotoxic T cell; Antigen presentation; Antigen processing; MHC restriction; Tumor antigen; Immunology; T cell; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008083541,0.0001939252,0.0001876304,0.0001008338,0.00008354908,0.0003334288,0.0000712406,0.0002482192,0.0006492634],"category_scores_gemma":[0.00008360375,0.00009934257,0.0001312864,0.00008830519,0.0001372549,0.0002253837,0.0001281964,0.000350722,0.000251034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002044075,"about_ca_system_score_gemma":0.0001217458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001257875,"about_ca_topic_score_gemma":0.0001734464,"domain_scores_codex":[0.9999194,0.00001191944,0.000004116373,0.00002326482,0.00002212701,0.00001901672],"domain_scores_gemma":[0.9999704,0.000004684739,0.00001091545,0.000002304365,0.000004861723,0.000006768909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003093667,0.000003107285,0.000111986,0.00001102544,0.000001110872,0.000007920939,0.000005558034,0.00004199786,0.9992741,0.00002595207,0.00001203397,0.000474239],"study_design_scores_gemma":[0.00001038323,0.0001241498,0.006739668,0.000007113177,0.00001132154,0.0001532174,0.0000473633,0.002116039,0.9882835,0.0001257843,0.00237491,0.000006516552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928444,0.001489906,0.004193788,0.00004756591,0.00002056908,0.00002110389,0.0003083649,0.00005678325,0.001017518],"genre_scores_gemma":[0.9954081,0.0007619697,0.00231316,0.00005899532,0.000006412691,0.00002394549,0.0002853076,0.00002370514,0.001118356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006492634,"threshold_uncertainty_score":0.002172053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05558056950259602,"score_gpt":0.3865183049597913,"score_spread":0.3309377354571953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}