{"id":"W2946460667","doi":"10.3390/cells8050475","title":"ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases","year":2019,"lang":"en","type":"article","venue":"Cells","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Biotechnology and Biological Sciences Research Council; Sigrid Juséliuksen Säätiö; Magnus Ehrnroothin Säätiö; Academy of Finland; Cancer Research UK; Helsingin Yliopisto","keywords":"Autophagy; Autophagosome; Cell biology; ULK1; Endoplasmic reticulum; Kinase; Biogenesis; Biology; BECN1; Autophagy-related protein 13; Chemistry; Biochemistry; Protein kinase A; Apoptosis; Protein phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001669983,0.0001041092,0.0002257641,0.00007585649,0.00001771758,0.000006642228,0.00009633355,0.00006187194,0.0007570648],"category_scores_gemma":[0.00001362511,0.00006990864,0.00006196891,0.0001669861,0.00007127724,0.00004179535,0.00001937598,0.00006963228,0.0000769953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009557056,"about_ca_system_score_gemma":0.00005863959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006650912,"about_ca_topic_score_gemma":0.000003167042,"domain_scores_codex":[0.9992387,0.00004090899,0.0002047998,0.0001817316,0.0001711563,0.0001627604],"domain_scores_gemma":[0.9994031,0.0001148149,0.00006855595,0.0003277307,0.00002716261,0.0000586226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002988792,0.000733229,0.2147399,0.0004157149,0.0001043016,0.0004138495,0.00254101,0.00001528732,0.771853,0.0004396762,0.001791772,0.006653319],"study_design_scores_gemma":[0.00121595,0.0002475729,0.4986228,0.00009081227,0.00003922225,0.00001842324,0.0003715666,0.0001080944,0.4967993,0.0003319839,0.002034802,0.0001194963],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995729,0.002585546,0.000002257275,0.0001825744,0.0001248473,0.0003563108,0.00002266828,0.00001644791,0.0009803869],"genre_scores_gemma":[0.9981087,0.000359838,0.00005690004,0.0006984342,0.00004167395,0.000008090488,0.00001765334,0.0000115938,0.0006970505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2838829,"threshold_uncertainty_score":0.8289329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009109832611255723,"score_gpt":0.2527787290366574,"score_spread":0.2436688964254017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}