{"id":"W2946460667","doi":"10.3390/cells8050475","title":"ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases","year":2019,"lang":"en","type":"article","venue":"Cells","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Biotechnology and Biological Sciences Research Council; Sigrid Juséliuksen Säätiö; Magnus Ehrnroothin Säätiö; Academy of Finland; Cancer Research UK; Helsingin Yliopisto","keywords":"Autophagy; Autophagosome; Cell biology; ULK1; Endoplasmic reticulum; Kinase; Biogenesis; Biology; BECN1; Autophagy-related protein 13; Chemistry; Biochemistry; Protein kinase A; Apoptosis; Protein phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003017549,0.0003902545,0.0004994099,0.0003351124,0.0002581511,0.0003580782,0.0002521785,0.0003064496,0.001115277],"category_scores_gemma":[0.0002696974,0.0003426861,0.0003086101,0.0001698525,0.000225612,0.000354966,0.0004815673,0.000546665,0.0006011368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005137581,"about_ca_system_score_gemma":0.0003414793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022787,"about_ca_topic_score_gemma":0.001226872,"domain_scores_codex":[0.9996587,0.00006727724,0.0000624893,0.00005593326,0.00009053134,0.00006512574],"domain_scores_gemma":[0.9997278,0.000059211,0.00005346116,0.00005294354,0.00003820887,0.0000683282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007258256,0.00001626333,0.00008320386,0.00004041971,0.000003869687,0.00002648444,0.00001003974,0.00005354164,0.9993238,0.00007732079,0.00004877431,0.0002437681],"study_design_scores_gemma":[0.00001085178,0.00006413019,0.002235685,0.000008881964,0.000008695739,0.0001596169,0.00001492121,0.001440918,0.994157,0.00004946758,0.001843191,0.000006656841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933935,0.001588917,0.002420341,0.000198559,0.00004657814,0.0000231745,0.0006832452,0.0001643944,0.00148138],"genre_scores_gemma":[0.9919147,0.0006647515,0.003283274,0.00007626219,0.00001257508,0.00004927427,0.001796476,0.00006285097,0.002139859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001115277,"threshold_uncertainty_score":0.003730953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009109832611255723,"score_gpt":0.2527787290366574,"score_spread":0.2436688964254017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}