{"id":"W2946503794","doi":"10.21873/anticanres.13344","title":"Intraductal Adaptation of the 4T1 Mouse Model of Breast Cancer Reveals Effects of the Epithelial Microenvironment on Tumor Progression and Metastasis","year":2019,"lang":"en","type":"article","venue":"Anticancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Scheme for Promotion of Academic and Research Collaboration; Ministry of Higher Education and Scientific Research","keywords":"Tumor microenvironment; Metastasis; Cancer research; Malignancy; Breast cancer; Mammary tumor; Cancer; Histopathology; Tumor progression; Pathology; Biology; Medicine; Internal medicine; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002905193,0.0005934312,0.0003133627,0.001289416,0.000259053,0.0004882761,0.0002762754,0.0005049336,0.002248066],"category_scores_gemma":[0.0001504527,0.0002896097,0.0004365884,0.0003803856,0.0005280753,0.0003363583,0.0003009794,0.001562378,0.0006400574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005852891,"about_ca_system_score_gemma":0.0002953167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008544197,"about_ca_topic_score_gemma":0.001594999,"domain_scores_codex":[0.9997017,0.00003357086,0.00002355365,0.00007503208,0.00009927186,0.00006681695],"domain_scores_gemma":[0.9996488,0.00005849145,0.0001263808,0.00004687011,0.00002928383,0.00009012961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001435392,0.00005701853,0.0004880932,0.00001911702,0.000003851367,0.00004135014,0.00001473137,0.00006478977,0.9983007,0.00009677291,0.00004749315,0.0007226201],"study_design_scores_gemma":[0.00001853393,0.0005312682,0.009300902,0.00001127739,0.00002006103,0.0004432689,0.0000751046,0.001144713,0.9862924,0.00009351706,0.002061571,0.00000728824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883457,0.001198197,0.005623813,0.0002912804,0.00004727702,0.00007495996,0.001575198,0.0002430084,0.002600474],"genre_scores_gemma":[0.9814714,0.001084572,0.007738348,0.0001221561,0.00001470319,0.0001483398,0.001995422,0.0001203164,0.007304795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002248066,"threshold_uncertainty_score":0.007520556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03565937495669595,"score_gpt":0.3420863279264731,"score_spread":0.3064269529697771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}