{"id":"W2946515961","doi":"10.1101/636779","title":"Evolution-driven attenuation of alphaviruses highlights key glycoprotein determinants regulating viral infectivity and dissemination","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University","keywords":"Arbovirus; Chikungunya; Alphavirus; Infectivity; Biology; Virology; Alphavirus infection; Viral evolution; Virus; Sindbis virus; Viral pathogenesis; Transmission (telecommunications); Computational biology; Genetics; Gene; Viral replication; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000193446,0.0001730412,0.0001236524,0.0001222632,0.0001089239,0.0002259855,0.0001289914,0.0001400613,0.0009116498],"category_scores_gemma":[0.0002150187,0.00006640855,0.0001011714,0.0001009161,0.000202126,0.0001673322,0.0002265395,0.0004800706,0.0001487488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003438365,"about_ca_system_score_gemma":0.0001795792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005645208,"about_ca_topic_score_gemma":0.0005345876,"domain_scores_codex":[0.9999313,0.00001540377,0.000004590747,0.000009658886,0.00002106474,0.0000178746],"domain_scores_gemma":[0.9999039,0.00003046116,0.00002764663,0.00001206689,0.0000117669,0.0000141229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006464936,0.00001351634,0.001186102,0.00001822118,0.000003966913,0.00004617577,0.00002113661,0.0006044891,0.9949182,0.0004449141,0.0000448508,0.002633826],"study_design_scores_gemma":[0.00002114566,0.0003272842,0.03608923,0.00002079259,0.00002930752,0.0005101924,0.0001280493,0.01789238,0.9370424,0.001621837,0.006304085,0.0000132637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957523,0.000432016,0.002024945,0.00007166472,0.000006687009,0.000005697077,0.00005378661,0.00002990634,0.001623042],"genre_scores_gemma":[0.9977822,0.0002623173,0.001072468,0.00003543679,0.000004318855,0.00000529512,0.00007533837,0.00001411498,0.0007486413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009116498,"threshold_uncertainty_score":0.003049791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009072187441144063,"score_gpt":0.2462843026644163,"score_spread":0.2372121152232722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}