{"id":"W2946559089","doi":"10.1016/s0140-6736(19)30654-3","title":"Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":367,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Ottawa; Montreal Children's Hospital; McGill University","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Wellcome Trust","keywords":"Medicine; Rickets; Pediatrics; Vitamin D and neurology; Short stature; Clinical endpoint; Hypophosphatemia; PHEX; Internal medicine; Adverse effect; Clinical trial; Randomized controlled trial; vitamin D deficiency","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001996282,0.002058476,0.005102935,0.0005208873,0.0005143721,0.001532239,0.001451963,0.003092369,0.008984503],"category_scores_gemma":[0.002572762,0.0007255321,0.003133772,0.0005270148,0.00194218,0.001505424,0.0006733435,0.005212639,0.001158586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001066283,"about_ca_system_score_gemma":0.001106089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001687211,"about_ca_topic_score_gemma":0.002818057,"domain_scores_codex":[0.9991434,0.0004333172,0.00004792433,0.0001710134,0.0000743912,0.00013001],"domain_scores_gemma":[0.9986669,0.0005987327,0.0002527558,0.0000847761,0.00006003214,0.0003368853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9846939,0.001653886,0.0003208036,0.0009808476,0.001186863,0.00005540112,0.00005305564,0.0002072783,0.0008602825,0.0001587984,0.000583162,0.009245747],"study_design_scores_gemma":[0.9805535,0.01777832,0.0005346339,0.0000652614,0.0003254604,0.0000339098,0.00002389412,0.0001175818,0.00007351916,0.00015662,0.0003284732,0.000008834891],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579817,0.02963111,0.001189781,0.002185699,0.001839746,0.002595291,0.001683431,0.0002261259,0.002667103],"genre_scores_gemma":[0.9741237,0.01115632,0.002459409,0.002228954,0.0007990033,0.003987588,0.001260948,0.00005082255,0.003933128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008984503,"threshold_uncertainty_score":0.03005618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05364377501152761,"score_gpt":0.350104969834705,"score_spread":0.2964611948231774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}