{"id":"W2946684713","doi":"10.3233/jad-181230","title":"A Bird’s-Eye View of the Multiple Biochemical Mechanisms that Propel Pathology of Alzheimer’s Disease: Recent Advances and Mechanistic Perspectives on How to Halt the Disease Progression Targeting Multiple Pathways","year":2019,"lang":"en","type":"review","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Oxidative stress; Disease; Autophagy; Mitochondrion; Proteasome; Neuroscience; Mechanism (biology); Biology; Neurodegeneration; Programmed cell death; Medicine; Bioinformatics; Cell biology; Pathology; Endocrinology; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002199492,0.001141737,0.001716092,0.001174877,0.0008891289,0.003130241,0.001366914,0.003382245,0.004564357],"category_scores_gemma":[0.001433382,0.0003695768,0.001091522,0.00081184,0.002147113,0.006585877,0.001574132,0.01005197,0.002087692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001072226,"about_ca_system_score_gemma":0.001738247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001533249,"about_ca_topic_score_gemma":0.002209424,"domain_scores_codex":[0.9993675,0.0001305812,0.00005175046,0.0001380476,0.0001931524,0.0001190668],"domain_scores_gemma":[0.9985025,0.0004645022,0.0000959723,0.00007417097,0.0005420369,0.0003208836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009569006,0.000398788,0.001104228,0.0129138,0.0003640983,0.00146263,0.0006953932,0.001122604,0.03072713,0.05447884,0.2511365,0.6446391],"study_design_scores_gemma":[0.00006448769,0.0007302846,0.001276511,0.002736472,0.0001998039,0.001849317,0.0007074308,0.0006525703,0.004430807,0.0316756,0.9555684,0.0001083836],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001107848,0.9444613,0.003766189,0.04215234,0.005016914,0.00001674754,0.00008248608,0.0001128493,0.003283267],"genre_scores_gemma":[0.009372175,0.961543,0.004127448,0.01415026,0.00473855,0.00003924523,0.0001337058,0.00003327722,0.005862326],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004564357,"threshold_uncertainty_score":0.01526928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07780576602726767,"score_gpt":0.3607902562837864,"score_spread":0.2829844902565187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}