{"id":"W2946712570","doi":"10.1007/978-1-4939-9220-1_6","title":"Design Strategy to Access siRNA-Encapsulating DNA “Nanosuitcases” That Can Conditionally Release Their Cargo","year":2019,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Oligonucleotide; DNA nanotechnology; DNA; Base pair; DNA origami; Nanotechnology; Computational biology; Scaffold; Chemistry; Computer science; Biology; Materials science; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002478328,0.0006413183,0.0002393448,0.0001662295,0.0002332581,0.0003693774,0.0004808705,0.0005209818,0.001050345],"category_scores_gemma":[0.0002183382,0.0002829088,0.0003610212,0.0001203068,0.0002179713,0.0003750944,0.0003364588,0.0007199675,0.000635432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004593786,"about_ca_system_score_gemma":0.0004038298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005036067,"about_ca_topic_score_gemma":0.0008201278,"domain_scores_codex":[0.9998275,0.00002064236,0.0000171352,0.00004513095,0.00004592953,0.00004360742],"domain_scores_gemma":[0.9998835,0.00001605369,0.00004011373,0.00001460753,0.00002386342,0.00002181056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003470198,0.00002349931,0.00007814398,0.00009498343,0.000009317076,0.0001134686,0.00003547526,0.0002315864,0.9947812,0.001760082,0.0001713608,0.002666066],"study_design_scores_gemma":[0.00000888977,0.00006363271,0.00009458118,0.000002262565,0.000009157542,0.00009350647,0.000008470521,0.0009759347,0.9947158,0.00007566437,0.003943784,0.000008383958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7938896,0.001605546,0.1890032,0.0007829795,0.0002267204,0.0007283385,0.0006887391,0.001578014,0.01149689],"genre_scores_gemma":[0.9391214,0.0008764862,0.05146072,0.0002569848,0.00002357615,0.0004281051,0.0005925313,0.0001011776,0.007139026],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001050345,"threshold_uncertainty_score":0.003513753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04469293784680911,"score_gpt":0.4040005320375559,"score_spread":0.3593075941907468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}