{"id":"W2946852702","doi":"10.1101/652644","title":"Vaccination against the digestive enzyme Cathepsin B using a YS1646 <i>Salmonella enterica</i> Typhimurium vector provides almost complete protection against <i>Schistosoma mansoni</i> challenge in a mouse model","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Biology; Schistosoma mansoni; Salmonella enterica; Microbiology; Cathepsin B; Cathepsin L; Cathepsin; Immunology; Cathepsin D; In vivo; Salmonella; Vaccination; Virology; Enzyme; Schistosomiasis; Helminths; Biochemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004541964,0.0008148905,0.000816353,0.0004287683,0.0004734456,0.0001689681,0.000748556,0.0008681616,0.0000185936],"category_scores_gemma":[0.0001566864,0.0007515295,0.0002771643,0.000375374,0.0001618399,0.000297362,0.0005137405,0.00196061,0.0002215397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009558312,"about_ca_system_score_gemma":0.0005727357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004092579,"about_ca_topic_score_gemma":0.00007680976,"domain_scores_codex":[0.9964145,0.0004993263,0.0008395913,0.001286845,0.0001558542,0.0008039174],"domain_scores_gemma":[0.9971508,0.0001260891,0.0008604073,0.001329905,0.0004573888,0.00007539612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002382369,0.0005130362,0.000983667,0.0002164848,0.0002528788,0.00002569173,0.0001757393,0.008662401,0.9886507,0.000125378,0.0001486636,0.000007124574],"study_design_scores_gemma":[0.004373896,0.0004078824,0.02441351,0.001934526,0.0004439949,0.000002337468,0.0001047533,0.1042897,0.8388821,0.000009136807,0.02171958,0.003418476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860209,0.0032548,0.003607969,0.0008521223,0.001754598,0.003077091,0.001052134,0.0003130617,0.00006737744],"genre_scores_gemma":[0.9975841,0.0005527555,0.0004217311,0.0002982131,0.0001646941,0.000673419,0.00001335427,0.0001649018,0.0001268415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1497685,"threshold_uncertainty_score":0.9994936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02856015337267217,"score_gpt":0.2430260355257557,"score_spread":0.2144658821530836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}