{"id":"W2946852702","doi":"10.1101/652644","title":"Vaccination against the digestive enzyme Cathepsin B using a YS1646 <i>Salmonella enterica</i> Typhimurium vector provides almost complete protection against <i>Schistosoma mansoni</i> challenge in a mouse model","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Biology; Schistosoma mansoni; Salmonella enterica; Microbiology; Cathepsin B; Cathepsin L; Cathepsin; Immunology; Cathepsin D; In vivo; Salmonella; Vaccination; Virology; Enzyme; Schistosomiasis; Helminths; Biochemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003239531,0.001012967,0.0006047987,0.0005973399,0.0002198894,0.0003390895,0.0003543101,0.0008690424,0.001946004],"category_scores_gemma":[0.0001139179,0.0003546196,0.0007530083,0.000208549,0.0004360764,0.0004092422,0.0001969115,0.001792958,0.0007456196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003237209,"about_ca_system_score_gemma":0.0002617977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001061864,"about_ca_topic_score_gemma":0.001165584,"domain_scores_codex":[0.9996643,0.00004488786,0.00004188005,0.00007887252,0.00006550158,0.0001045961],"domain_scores_gemma":[0.9996836,0.00002879571,0.0001042712,0.00003228124,0.00003498096,0.0001159583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008866559,0.0005629439,0.0001820842,0.00006040281,0.00001190435,0.00003720166,0.00001832719,0.00006730745,0.9971096,0.00005543338,0.0001417686,0.0008664515],"study_design_scores_gemma":[0.000189706,0.01063268,0.003608384,0.00002265594,0.00004815879,0.0002729084,0.00004747532,0.0007768077,0.9823195,0.00002831914,0.002041656,0.00001175481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933122,0.0006436195,0.002111024,0.0002543031,0.000144877,0.0001593837,0.001168517,0.0003595025,0.001846658],"genre_scores_gemma":[0.9818902,0.000982512,0.00317625,0.0002339474,0.00005165371,0.0002026624,0.002984893,0.00008225651,0.01039562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001946004,"threshold_uncertainty_score":0.006510019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02856015337267217,"score_gpt":0.2430260355257557,"score_spread":0.2144658821530836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}