{"id":"W2946853949","doi":"10.1074/jbc.ra118.006394","title":"Structure of Ddi2, a highly inducible detoxifying metalloenzyme from Saccharomyces cerevisiae","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Cyanamide; Active site; Chemistry; Saccharomyces cerevisiae; Biochemistry; Binding site; Enzyme; Stereochemistry; Zinc; Yeast; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150212,0.0001584175,0.0003732681,0.0000202517,0.00002449773,0.00001387598,0.0004132626,0.0002783274,0.0003606702],"category_scores_gemma":[0.0001222163,0.0001092206,0.0002080554,0.00009715086,0.00007349937,0.000006734995,0.0001177292,0.000214357,0.000004607743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008016728,"about_ca_system_score_gemma":0.00006589184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005089535,"about_ca_topic_score_gemma":4.299601e-7,"domain_scores_codex":[0.998961,0.00003304928,0.0004621435,0.0002309736,0.0001434806,0.000169379],"domain_scores_gemma":[0.9989458,0.00003440185,0.0004936806,0.0003021029,0.0001206868,0.0001032867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005549078,0.00005260183,0.004186535,0.00002208125,0.00009264262,0.000001514736,0.000008649089,0.000009297782,0.9947147,0.00001774548,0.0002433839,0.0005953063],"study_design_scores_gemma":[0.0004571239,0.00009905211,0.004542911,0.00002637516,0.00003779507,0.00003376833,0.00007365565,0.000002864861,0.9820253,0.0003068264,0.0122652,0.0001291187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946584,0.00440968,0.0001103318,0.00008194023,0.00008711126,0.00006385587,0.0001227489,0.000004040786,0.000461896],"genre_scores_gemma":[0.996892,0.0004211573,0.001872928,0.0000875214,0.0004870828,0.000001242527,0.00007741834,0.000009570626,0.0001510527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01268944,"threshold_uncertainty_score":0.4453888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397497113021285,"score_gpt":0.2468451366398016,"score_spread":0.2328701655095888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}