{"id":"W2946853949","doi":"10.1074/jbc.ra118.006394","title":"Structure of Ddi2, a highly inducible detoxifying metalloenzyme from Saccharomyces cerevisiae","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Cyanamide; Active site; Chemistry; Saccharomyces cerevisiae; Biochemistry; Binding site; Enzyme; Stereochemistry; Zinc; Yeast; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005433858,0.0005644436,0.0002427908,0.0002141743,0.0002041259,0.0003696446,0.0005106216,0.0003164933,0.001821058],"category_scores_gemma":[0.0001182721,0.0001816289,0.0002557235,0.0004327816,0.0001762719,0.0001984849,0.0001057065,0.0007248444,0.0006180183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007138627,"about_ca_system_score_gemma":0.0003931013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006169608,"about_ca_topic_score_gemma":0.004258227,"domain_scores_codex":[0.9999716,0.000002294694,0.000002273895,0.00001067548,0.000008335301,0.00000482724],"domain_scores_gemma":[0.999909,0.0000072935,0.00002222158,0.00001117021,0.00001958431,0.00003079946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005626813,0.0000572894,0.0005811984,0.0001274437,0.00002473095,0.0006068318,0.00005415125,0.0006483446,0.9932766,0.0008068464,0.0007746001,0.002479313],"study_design_scores_gemma":[0.0002331194,0.0006860856,0.022181,0.00003308856,0.00009942217,0.001829978,0.0001889656,0.006143671,0.9293647,0.0007681255,0.03840661,0.00006528129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9612736,0.003993275,0.01261481,0.0007858726,0.0002892683,0.0001233746,0.01083677,0.000648953,0.009434097],"genre_scores_gemma":[0.9530682,0.001577112,0.007867905,0.0001677271,0.00004493854,0.00007686403,0.0261964,0.000158394,0.01084251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006169608,"threshold_uncertainty_score":0.01226741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397497113021285,"score_gpt":0.2468451366398016,"score_spread":0.2328701655095888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}