{"id":"W2946884236","doi":"10.1186/s40425-019-0575-3","title":"CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids","year":2019,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Roche Innovation Center Zurich; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Sociedad Española de Oncología Médica; Cancer Research UK; Wellcome Trust","keywords":"Medicine; Colorectal cancer; Immunotherapy; Cancer immunotherapy; Organoid; Bispecific antibody; Cancer research; Antibody; Immunology; Cancer; Monoclonal antibody; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009038764,0.0001342065,0.0001758768,0.0001880463,0.0001388593,0.0003213581,0.0001043116,0.0001896302,0.001429497],"category_scores_gemma":[0.0001665213,0.0001533631,0.0002113851,0.0001472886,0.0001354048,0.0001437351,0.0001933531,0.0005402695,0.0003713982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002455277,"about_ca_system_score_gemma":0.0001369629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001639172,"about_ca_topic_score_gemma":0.001578892,"domain_scores_codex":[0.9998549,0.00001907308,0.00001694398,0.00003283759,0.00002938298,0.00004678606],"domain_scores_gemma":[0.999855,0.00003332749,0.00002211706,0.00002408033,0.00001362602,0.00005179388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002059752,0.0000432617,0.00170704,0.00001017187,0.000005815991,0.0001128101,0.00004516414,0.00007858456,0.9968862,0.0000965888,0.00006534447,0.0007430413],"study_design_scores_gemma":[0.00005271381,0.001224243,0.07406849,0.000006162948,0.0000442749,0.002352367,0.0002612721,0.003302259,0.9153796,0.0001152234,0.00317913,0.00001431393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985973,0.0001079193,0.0004605256,0.00002031057,0.000004868196,0.00001248773,0.0002029587,0.00001942608,0.0005741684],"genre_scores_gemma":[0.99839,0.00007388905,0.0003943357,0.00002426356,0.000002380659,0.00001886025,0.0004366014,0.00001022469,0.000649485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001639172,"threshold_uncertainty_score":0.00478214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788892149129567,"score_gpt":0.3402455607845739,"score_spread":0.3223566392932782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}