{"id":"W2946884236","doi":"10.1186/s40425-019-0575-3","title":"CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids","year":2019,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Roche Innovation Center Zurich; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Sociedad Española de Oncología Médica; Cancer Research UK; Wellcome Trust","keywords":"Medicine; Colorectal cancer; Immunotherapy; Cancer immunotherapy; Organoid; Bispecific antibody; Cancer research; Antibody; Immunology; Cancer; Monoclonal antibody; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005040831,0.0003336643,0.0007175234,0.0002128647,0.0003308296,0.00008323494,0.0003107724,0.0001478354,0.000908101],"category_scores_gemma":[0.00005395068,0.0002149324,0.0002369482,0.0002960763,0.0001767311,0.0001643661,0.00007368249,0.0005798349,0.000007969147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002577235,"about_ca_system_score_gemma":0.0003716341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004393881,"about_ca_topic_score_gemma":0.0005206733,"domain_scores_codex":[0.9973552,0.0001557112,0.000790178,0.0004052137,0.0006786899,0.0006149656],"domain_scores_gemma":[0.998482,0.0002876956,0.0003843388,0.000240847,0.0004390656,0.0001660666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0163347,0.0001451107,0.07867897,0.0001420363,0.0002530748,0.000009336793,0.001546975,0.0001277993,0.8936099,0.00001443189,0.001358155,0.007779447],"study_design_scores_gemma":[0.006174091,0.001217446,0.1770268,0.001075186,0.00002758641,0.00003933626,0.0004817582,0.00022823,0.701502,0.0000624746,0.1118041,0.0003610179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703004,0.02443002,0.0002238789,0.002695833,0.0007578928,0.001311583,0.000190307,0.0000139377,0.0000761076],"genre_scores_gemma":[0.9822976,0.01520472,0.0005429946,0.0007506951,0.0003349771,0.0000971851,0.00001787489,0.00007126783,0.0006826812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.192108,"threshold_uncertainty_score":0.9943069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788892149129567,"score_gpt":0.3402455607845739,"score_spread":0.3223566392932782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}