{"id":"W2946921489","doi":"10.1093/jnci/djz109","title":"Genetically Predicted Levels of DNA Methylation Biomarkers and Breast Cancer Risk: Data From 228 951 Women of European Descent","year":2019,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"College of Graduate Studies; National Cancer Institute; Ministero dello Sviluppo Economico; National Institutes of Health; Vanderbilt University Medical Center; Cancer Research UK; Government of Canada; Fondation du cancer du sein du Québec; Vanderbilt University; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Canadian Institutes of Health Research; Genome Canada; European Commission","keywords":"DNA methylation; Breast cancer; CpG site; Genome-wide association study; Cancer; Methylation; Oncology; Biology; Framingham Heart Study; Genetics; Internal medicine; Medicine; Framingham Risk Score; Gene; Single-nucleotide polymorphism; Gene expression; Genotype; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001492129,0.0003464007,0.0005723537,0.00054348,0.000323405,0.0003161034,0.0004597315,0.00050598,0.001500496],"category_scores_gemma":[0.003583848,0.0002827039,0.0005833841,0.0009564178,0.0002891446,0.0001831733,0.0004181921,0.000303477,0.0003966773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002395201,"about_ca_system_score_gemma":0.0002163633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009017756,"about_ca_topic_score_gemma":0.006225017,"domain_scores_codex":[0.9990891,0.0003273354,0.0001043428,0.0003008027,0.0001239843,0.00005438815],"domain_scores_gemma":[0.998463,0.0006669486,0.0003517674,0.0002903965,0.0001246501,0.0001033458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002978959,0.00004362045,0.9956211,0.00001544263,0.0002231205,0.0001011522,0.0001026137,0.0003556799,0.0007151141,0.00002199149,0.0001678332,0.002334342],"study_design_scores_gemma":[0.00003577279,0.0001618816,0.9972005,0.00000879508,0.0001112915,0.0003640677,0.0001225452,0.001079698,0.0003133929,0.00005428591,0.0005398781,0.000007870674],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971955,0.00009659932,0.0004606066,0.00001538493,0.000001814171,0.00001124087,0.002049402,0.000006515137,0.0001629807],"genre_scores_gemma":[0.9949335,0.00007653092,0.0005087179,0.00002126154,0.000003190516,0.00003660637,0.004205098,0.000006156682,0.0002088108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009017756,"threshold_uncertainty_score":0.01793057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04097450727309892,"score_gpt":0.3079329739233212,"score_spread":0.2669584666502223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}