{"id":"W2946933805","doi":"10.3389/fphar.2019.00617","title":"Treatment-Resistant Schizophrenia: Insights From Genetic Studies and Machine Learning Approaches","year":2019,"lang":"en","type":"review","venue":"Frontiers in Pharmacology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Regione Autonoma della Sardegna; Fondazione di Sardegna","keywords":"Schizophrenia (object-oriented programming); Genetic architecture; Clozapine; Genome-wide association study; Disease; Medicine; Genetic association; Candidate gene; Psychiatry; Phenotype; Biology; Genetics; Gene; Genotype; Single-nucleotide polymorphism; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002398459,0.0006011712,0.001025866,0.001784529,0.0002057483,0.001168404,0.0005108762,0.0007717233,0.001175631],"category_scores_gemma":[0.00317821,0.0002132016,0.0006970413,0.001716561,0.0008900482,0.0009742861,0.0006361364,0.001284151,0.0002659685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008808223,"about_ca_system_score_gemma":0.001315151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002034008,"about_ca_topic_score_gemma":0.002783893,"domain_scores_codex":[0.9994102,0.000239783,0.00006363574,0.0001038577,0.0001458138,0.0000367983],"domain_scores_gemma":[0.9977306,0.001733009,0.0002035281,0.00005811834,0.0002069616,0.00006790058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002000052,0.00009223472,0.0108093,0.00789383,0.0008765528,0.000659647,0.0002786297,0.001413171,0.00208744,0.02530776,0.007163761,0.9432176],"study_design_scores_gemma":[0.0001615195,0.0008982409,0.11654,0.02275433,0.002847965,0.007677923,0.0007151389,0.004959929,0.002637998,0.2313793,0.6091629,0.0002648673],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002831263,0.9867504,0.003600188,0.005012517,0.0001431022,0.00001088624,0.0001070707,0.00001854423,0.001526029],"genre_scores_gemma":[0.01675512,0.9783538,0.003241245,0.0008449808,0.0004201112,0.00001916515,0.0001087748,0.000006912816,0.0002500098],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002398459,"threshold_uncertainty_score":0.0126844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07864059622635458,"score_gpt":0.3311565314073106,"score_spread":0.2525159351809561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}