{"id":"W2946933805","doi":"10.3389/fphar.2019.00617","title":"Treatment-Resistant Schizophrenia: Insights From Genetic Studies and Machine Learning Approaches","year":2019,"lang":"en","type":"review","venue":"Frontiers in Pharmacology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Regione Autonoma della Sardegna; Fondazione di Sardegna","keywords":"Schizophrenia (object-oriented programming); Genetic architecture; Clozapine; Genome-wide association study; Disease; Medicine; Genetic association; Candidate gene; Psychiatry; Phenotype; Biology; Genetics; Gene; Genotype; Single-nucleotide polymorphism; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001232983,0.0005601574,0.002047402,0.0002285508,0.0001096013,0.00001267159,0.0002473994,0.0006922586,0.00001068553],"category_scores_gemma":[0.00008603533,0.0004495904,0.0002589324,0.0001432715,0.0002028782,0.000003001203,0.0002452817,0.0003672148,0.00001281701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001692425,"about_ca_system_score_gemma":0.0002016045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004158674,"about_ca_topic_score_gemma":0.00004664479,"domain_scores_codex":[0.9969378,0.0009976756,0.0006567529,0.0009195978,0.00007005997,0.0004181402],"domain_scores_gemma":[0.9990482,0.000141712,0.0004185613,0.0002698714,0.00003071405,0.00009092945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002176974,0.0001508209,0.003795318,0.001974113,0.005166113,0.00005008862,0.0001975943,0.0003653079,0.0001711208,0.00001334479,0.007013582,0.9808849],"study_design_scores_gemma":[0.001494528,0.0004465257,0.0002256591,0.0001853292,0.001527373,0.00001117263,0.0001068456,0.0004305423,0.00001640455,0.0001450876,0.9949527,0.0004578827],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00494886,0.9922155,0.0002980056,0.0000380182,0.00158871,0.000734131,0.00008035655,0.00001379841,0.00008268363],"genre_scores_gemma":[0.001344745,0.9897265,0.006571282,0.00005536288,0.0004918458,0.0002939467,0.0006703007,0.00006425965,0.0007817158],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9879391,"threshold_uncertainty_score":0.9997956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07864059622635458,"score_gpt":0.3311565314073106,"score_spread":0.2525159351809561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}