{"id":"W2946972694","doi":"10.1016/j.biopsych.2019.03.985","title":"The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder","year":2019,"lang":"en","type":"review","venue":"Biological Psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Dalhousie University","funders":"European Regional Development Fund; Medical Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; School of Medicine; National Institutes of Health; H. Lundbeck A/S; Norges Idrettshøgskole; Norges Forskningsråd; Vetenskapsrådet; National Institute of Mental Health; Stockholms Läns Landsting; Knut och Alice Wallenbergs Stiftelse; Ministerio de Economía y Competitividad; National Health and Medical Research Council; Ege Üniversitesi; Marie Curie; Deutsche Forschungsgemeinschaft; Ministerstvo Zdravotnictví Ceské Republiky; European Commission; King's College London; National Institute on Aging; Dokuz Eylül Üniversitesi; Department of Health and Aged Care, Australian Government; National Institute for Health and Care Research; Wellcome Trust; University College London; Nova Scotia Health Research Foundation; Lieber Institute for Brain Development; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; ASCRS Research Foundation; Dalhousie University; King’s College London; Otsuka Pharmaceutical; Karolinska Institutet; National Alliance for Research on Schizophrenia and Depression; ZonMw; Instituto de Salud Carlos III; Boehringer Ingelheim; Fundación Alicia Koplowitz; BrainsWay; Biogen; British Medical Association; National Science Foundation; Stanley Medical Research Institute; Cilag; Brain and Behavior Research Foundation","keywords":"Schizophrenia (object-oriented programming); Bipolar disorder; Association (psychology); Psychiatry; Disease; Psychology; First-degree relatives; Medicine; Clinical psychology; Internal medicine; Family history; Psychotherapist; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006048282,0.0004082343,0.001261795,0.0001273033,0.0002507455,0.00005164252,0.0001672109,0.0003312044,0.00004025818],"category_scores_gemma":[0.0002983671,0.0002001001,0.0002508652,0.0001890808,0.0002137259,0.00005271454,0.0001401179,0.0005597019,0.00002663054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000589323,"about_ca_system_score_gemma":0.0002188573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008153479,"about_ca_topic_score_gemma":0.00007795871,"domain_scores_codex":[0.997136,0.001006073,0.0005594188,0.0005984724,0.000362759,0.000337291],"domain_scores_gemma":[0.9976282,0.001081338,0.0004412193,0.0004705065,0.000048617,0.0003300812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009042731,0.0004277792,0.6081038,0.0005561848,0.0007534856,0.000002200922,0.00006396495,8.098704e-9,3.752266e-8,0.000631207,0.0001947497,0.3883623],"study_design_scores_gemma":[0.003028375,0.002506425,0.7253504,0.0006315106,0.001245209,0.000002474034,0.00047948,9.219268e-7,2.319656e-8,0.001071411,0.2654445,0.0002392446],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1809878,0.8163537,0.000002129367,0.0002213163,0.0001397478,0.001755349,0.0004575599,0.00003074058,0.0000516124],"genre_scores_gemma":[0.01275926,0.9857645,0.0002071166,0.00001400202,0.0004642601,0.00007648118,0.0001377052,0.00003773807,0.0005389562],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3881231,"threshold_uncertainty_score":0.8159845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06726998075388474,"score_gpt":0.3505904253384202,"score_spread":0.2833204445845354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}