{"id":"W2946972694","doi":"10.1016/j.biopsych.2019.03.985","title":"The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder","year":2019,"lang":"en","type":"review","venue":"Biological Psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Dalhousie University","funders":"European Regional Development Fund; Medical Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; School of Medicine; National Institutes of Health; H. Lundbeck A/S; Norges Idrettshøgskole; Norges Forskningsråd; Vetenskapsrådet; National Institute of Mental Health; Stockholms Läns Landsting; Knut och Alice Wallenbergs Stiftelse; Ministerio de Economía y Competitividad; National Health and Medical Research Council; Ege Üniversitesi; Marie Curie; Deutsche Forschungsgemeinschaft; Ministerstvo Zdravotnictví Ceské Republiky; European Commission; King's College London; National Institute on Aging; Dokuz Eylül Üniversitesi; Department of Health and Aged Care, Australian Government; National Institute for Health and Care Research; Wellcome Trust; University College London; Nova Scotia Health Research Foundation; Lieber Institute for Brain Development; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; ASCRS Research Foundation; Dalhousie University; King’s College London; Otsuka Pharmaceutical; Karolinska Institutet; National Alliance for Research on Schizophrenia and Depression; ZonMw; Instituto de Salud Carlos III; Boehringer Ingelheim; Fundación Alicia Koplowitz; BrainsWay; Biogen; British Medical Association; National Science Foundation; Stanley Medical Research Institute; Cilag; Brain and Behavior Research Foundation","keywords":"Schizophrenia (object-oriented programming); Bipolar disorder; Association (psychology); Psychiatry; Disease; Psychology; First-degree relatives; Medicine; Clinical psychology; Internal medicine; Family history; Psychotherapist; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009562552,0.0006216612,0.001526706,0.00123534,0.0001606552,0.0007029344,0.0007656257,0.0007097499,0.002025527],"category_scores_gemma":[0.00165478,0.0001944716,0.0007975788,0.001475131,0.0003093769,0.0004816102,0.0005856323,0.0008139698,0.0002980334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003540036,"about_ca_system_score_gemma":0.0009498834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00375143,"about_ca_topic_score_gemma":0.008373312,"domain_scores_codex":[0.9997877,0.00005302798,0.00004781376,0.00004536645,0.00005159951,0.00001445902],"domain_scores_gemma":[0.9993306,0.0004384755,0.0001268982,0.00001393003,0.00006107084,0.00002895763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0004150797,0.0000499551,0.005353776,0.03757183,0.002740073,0.0005968176,0.0001314169,0.0002244059,0.0005619864,0.001880641,0.01305329,0.9374207],"study_design_scores_gemma":[0.0004338234,0.0004293911,0.07753208,0.06887824,0.0192303,0.007698908,0.0006981228,0.0002512643,0.0004895253,0.008416734,0.8157709,0.0001706808],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002839293,0.9993679,0.00002634891,0.0001377462,0.00003632212,0.000001171788,0.00001976209,0.000001235598,0.0001255055],"genre_scores_gemma":[0.002088469,0.9974528,0.0001033094,0.0001713751,0.00007299385,0.000002262664,0.00003348901,6.67415e-7,0.00007461951],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00375143,"threshold_uncertainty_score":0.007459164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06726998075388474,"score_gpt":0.3505904253384202,"score_spread":0.2833204445845354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}