{"id":"W2946995393","doi":"10.1101/633867","title":"Phosphatidylinositol Cycle Disruption is Central to Atypical Hemolytic-Uremic Syndrome Caused by Diacylglycerol Kinase Epsilon Deficiency","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Sickkids Research Institute; Canadian Institutes of Health Research; Hospital for Sick Children; Canadian Child Health Clinician Scientist Program","keywords":"Diacylglycerol kinase; Phosphatidylinositol; Lipidomics; Phospholipase C; Atypical hemolytic uremic syndrome; Diglyceride; Chemistry; Biochemistry; Biology; Kinase; Endocrinology; Internal medicine; Protein kinase C; Medicine; Signal transduction; Immunology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107522,0.0003573702,0.0001810196,0.0003287055,0.0001260685,0.0002174853,0.0001818053,0.0003951248,0.0009320532],"category_scores_gemma":[0.0002340356,0.0001041758,0.0001895433,0.0002134866,0.0002680785,0.0001359816,0.0002772934,0.0004047216,0.000188721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000218414,"about_ca_system_score_gemma":0.0001017983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004683057,"about_ca_topic_score_gemma":0.0006189033,"domain_scores_codex":[0.9998543,0.00001599939,0.00001770304,0.00004645352,0.00004510204,0.00002040888],"domain_scores_gemma":[0.9998665,0.0000246491,0.00005516538,0.00001094589,0.000009684194,0.00003308378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002141236,0.00002009843,0.002433675,0.00003935885,0.00001547436,0.002130934,0.00002471251,0.0001097818,0.9926952,0.0001614238,0.00007598543,0.002079254],"study_design_scores_gemma":[0.00003845426,0.0002095318,0.07470803,0.00002023601,0.00007258177,0.01552498,0.0001383418,0.00324247,0.9017543,0.0005258839,0.003743239,0.00002199667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946015,0.0004851127,0.00378728,0.0001041402,0.00002395433,0.00001594469,0.0003911996,0.00008101319,0.000509806],"genre_scores_gemma":[0.9973881,0.0002310281,0.001509683,0.00007687938,0.000004328102,0.00001308528,0.0002575403,0.00001198964,0.0005074497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009320532,"threshold_uncertainty_score":0.003118098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010057827479736,"score_gpt":0.2292444445375291,"score_spread":0.2191438662627318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}