{"id":"W2946995821","doi":"10.1200/jco.2019.37.15_suppl.e13021","title":"Confirmation of germline variants identified by tumor testing: A population-based study.","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Medicine; HRAS; Neuroblastoma RAS viral oncogene homolog; Oncology; KRAS; Internal medicine; PDGFRA; SDHD; SDHB; Cancer; Genetic testing; Germline; Population; PTEN; Colorectal cancer; Germline mutation; GiST; Genetics; Mutation; Stromal cell; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004187773,0.0003950845,0.0002794799,0.001189338,0.0007603854,0.0006808992,0.0003963347,0.0006306214,0.002360385],"category_scores_gemma":[0.001694955,0.000427479,0.0003005952,0.00148708,0.000577867,0.0005097783,0.0005894464,0.0006328902,0.0005709376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005090012,"about_ca_system_score_gemma":0.0004860717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01550015,"about_ca_topic_score_gemma":0.01464795,"domain_scores_codex":[0.9993294,0.00008245823,0.00005488535,0.0002715182,0.0001649033,0.00009686164],"domain_scores_gemma":[0.9991617,0.0001740747,0.0003254237,0.0000683516,0.00009706627,0.0001733566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005623637,0.00004934149,0.9967049,0.00000676758,0.0000218848,0.001248035,0.0001429291,0.00002293774,0.0004956283,0.00001365663,0.0001095157,0.001128097],"study_design_scores_gemma":[0.0000102391,0.0001741934,0.9925506,0.000006885533,0.0000291396,0.00635378,0.0002846761,0.000160511,0.0001119461,0.00002595306,0.0002855481,0.000006539609],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988249,0.00009256473,0.0001141835,0.00002092165,0.000002196198,0.00002057691,0.0003494642,0.000005346902,0.0005698676],"genre_scores_gemma":[0.9993932,0.00007751377,0.00006002993,0.00003861604,0.000004358451,0.00000931085,0.0002781315,0.000003685532,0.0001351209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01550015,"threshold_uncertainty_score":0.03081989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06173140254786654,"score_gpt":0.4108980837037009,"score_spread":0.3491666811558344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}