{"id":"W2947089828","doi":"10.1186/s13059-019-1678-3","title":"Linking CRISPR-Cas9 interference in cassava to the evolution of editing-resistant geminiviruses","year":2019,"lang":"en","type":"article","venue":"Genome biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eidgenössische Technische Hochschule Zürich; European Commission","keywords":"CRISPR; Biology; Cas9; Genetics; Virus; Genome editing; Nicotiana benthamiana; Virology; Genome; Geminiviridae; DNA virus; Plant virus; Computational biology; Gene; Begomovirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000227565,0.0001055013,0.0001419228,0.00007067364,0.00002009681,0.000005247037,0.000247797,0.0001165255,0.00002399628],"category_scores_gemma":[0.00006467137,0.00008368491,0.0000444543,0.0001104934,0.00003519016,0.000001352902,0.0001714367,0.00008329417,0.00002831694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003319856,"about_ca_system_score_gemma":0.00004178195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001286842,"about_ca_topic_score_gemma":0.0004015858,"domain_scores_codex":[0.9992116,0.00004364083,0.0002184333,0.0002581278,0.00003845746,0.0002297288],"domain_scores_gemma":[0.9995424,0.00002134379,0.00005275356,0.0003076779,0.000043952,0.00003189796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004317177,0.000011848,0.02214436,0.00001903216,0.00001286295,5.334965e-7,0.0001593309,0.001364612,0.9751535,0.0001946451,0.00005241784,0.000843703],"study_design_scores_gemma":[0.001385159,0.002982154,0.2046853,0.0001609368,0.00003847109,0.00003613514,0.002400493,0.0007085095,0.6047214,0.0004407428,0.1815424,0.0008982675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751418,0.001820971,0.02157385,0.0001204979,0.0004261352,0.000199542,0.00002520365,0.000006344395,0.0006856921],"genre_scores_gemma":[0.9991418,0.0000467319,0.0003118087,0.00008831137,0.0002413532,0.0000136975,0.00002631249,0.00001061802,0.000119363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3704321,"threshold_uncertainty_score":0.3412572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049782100557855,"score_gpt":0.2983863012227961,"score_spread":0.2878884802172176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}