{"id":"W2947089828","doi":"10.1186/s13059-019-1678-3","title":"Linking CRISPR-Cas9 interference in cassava to the evolution of editing-resistant geminiviruses","year":2019,"lang":"en","type":"article","venue":"Genome biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eidgenössische Technische Hochschule Zürich; European Commission","keywords":"CRISPR; Biology; Cas9; Genetics; Virus; Genome editing; Nicotiana benthamiana; Virology; Genome; Geminiviridae; DNA virus; Plant virus; Computational biology; Gene; Begomovirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003704185,0.0003239524,0.0002765858,0.0002981173,0.000281768,0.0005753738,0.0003358848,0.0004705339,0.000700182],"category_scores_gemma":[0.0004108928,0.0001688648,0.0003110301,0.0001868306,0.0003019779,0.0001474562,0.0005340376,0.0006052583,0.0002800924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005923375,"about_ca_system_score_gemma":0.00031264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008635782,"about_ca_topic_score_gemma":0.001332988,"domain_scores_codex":[0.9997119,0.00004151761,0.00004406443,0.00008125312,0.00006878727,0.00005244],"domain_scores_gemma":[0.9996662,0.0001027865,0.0001003956,0.00005825542,0.00002926656,0.00004306051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006119943,0.00001789152,0.0006655374,0.00003653538,0.00001054482,0.000109792,0.00004025935,0.0003745144,0.9963593,0.0002390998,0.00003843127,0.002046844],"study_design_scores_gemma":[0.00001261589,0.0001994876,0.005050294,0.00001571808,0.00004050603,0.0005444077,0.00005529758,0.004992258,0.9831349,0.0001990945,0.005737802,0.00001762668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822365,0.0006297719,0.01385329,0.00009705179,0.00005138436,0.00006768804,0.0002233713,0.0002596188,0.002581256],"genre_scores_gemma":[0.9876772,0.0003982005,0.008987286,0.00005254114,0.000006180244,0.00005329622,0.0004568287,0.00007258343,0.002296048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008635782,"threshold_uncertainty_score":0.004297733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049782100557855,"score_gpt":0.2983863012227961,"score_spread":0.2878884802172176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}