{"id":"W2947122397","doi":"10.1016/j.omtm.2019.05.010","title":"RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Memorial University of Newfoundland; RIKEN; Japan Agency for Medical Research and Development; Mayo Clinic","keywords":"Induced pluripotent stem cell; Biology; Transduction (biophysics); Gene delivery; Somatic cell; Cell biology; Transgene; Gene; Viral vector; Cellular differentiation; Genetic enhancement; Embryonic stem cell; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002222671,0.0003372235,0.0004853136,0.0001173351,0.00009285312,0.00003596935,0.0003137328,0.0002474929,0.00005730159],"category_scores_gemma":[0.0002088682,0.0002824482,0.0001575397,0.0002489708,0.0001661248,0.00000461057,0.00009831375,0.0002322698,0.00001415114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004142131,"about_ca_system_score_gemma":0.0003651662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001002838,"about_ca_topic_score_gemma":0.00001220589,"domain_scores_codex":[0.9959944,0.001405937,0.0008903407,0.0008480301,0.0004518555,0.0004094438],"domain_scores_gemma":[0.9982537,0.0002776561,0.0003290722,0.0006923822,0.0002671523,0.0001800409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002752866,0.0002496328,0.003413723,0.0000440931,0.0002247832,0.000001659097,0.0001665377,0.001453543,0.8239563,0.00001292018,0.000002277258,0.1677217],"study_design_scores_gemma":[0.002966327,0.003271285,0.04718414,0.00004254978,0.00002045968,0.000001814293,0.00005643472,0.0050183,0.9402827,0.00004288072,0.0007331053,0.0003799969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7426484,0.0009990472,0.2554002,0.00008459592,0.00007451972,0.0007402399,0.00000684028,0.00001455662,0.00003155671],"genre_scores_gemma":[0.791502,0.0001579814,0.2077831,0.000256268,0.0000259027,0.00009906234,0.00007208721,0.00004865785,0.00005490115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1673416,"threshold_uncertainty_score":0.9999627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04849974910080472,"score_gpt":0.3921997750134708,"score_spread":0.3437000259126661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}