{"id":"W2947122397","doi":"10.1016/j.omtm.2019.05.010","title":"RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Memorial University of Newfoundland; RIKEN; Japan Agency for Medical Research and Development; Mayo Clinic","keywords":"Induced pluripotent stem cell; Biology; Transduction (biophysics); Gene delivery; Somatic cell; Cell biology; Transgene; Gene; Viral vector; Cellular differentiation; Genetic enhancement; Embryonic stem cell; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003021332,0.0003780698,0.0002793007,0.0002696529,0.0001430067,0.0003221437,0.0002701786,0.0004028562,0.0007423596],"category_scores_gemma":[0.0002246525,0.0001839367,0.0002519058,0.0001492688,0.0002669066,0.0002831236,0.0002611298,0.000661312,0.0003722207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000203529,"about_ca_system_score_gemma":0.0003330628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000277983,"about_ca_topic_score_gemma":0.0003385047,"domain_scores_codex":[0.9996804,0.00003820246,0.00004178789,0.00007442522,0.0001217714,0.00004336153],"domain_scores_gemma":[0.9998708,0.00002492062,0.00004544522,0.00002115232,0.00002138466,0.00001640337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009952578,0.000005454473,0.00002876511,0.00001691265,0.00000157038,0.00002745663,0.000006871317,0.0000349171,0.9986423,0.0001716621,0.00001968952,0.001034432],"study_design_scores_gemma":[0.000003722701,0.00006700078,0.0003087593,0.000003091594,0.000007952295,0.0002304711,0.000005418151,0.0007392348,0.9958329,0.00003396328,0.002763886,0.000003625636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8182429,0.002802801,0.1724835,0.0001937299,0.0001250332,0.0003099165,0.001099191,0.001085724,0.003657215],"genre_scores_gemma":[0.9385028,0.001945738,0.05094107,0.0001190311,0.00002978176,0.0002647238,0.001902871,0.0002198104,0.00607435],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0007423596,"threshold_uncertainty_score":0.002483368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04849974910080472,"score_gpt":0.3921997750134708,"score_spread":0.3437000259126661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}