{"id":"W2947217637","doi":"10.1186/s12885-019-5600-x","title":"Rationale and design of the German-speaking myeloma multicenter group (GMMG) trial HD6: a randomized phase III trial on the effect of elotuzumab in VRD induction/consolidation and lenalidomide maintenance in patients with newly diagnosed myeloma","year":2019,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Research and Development; Bristol-Myers Squibb Canada; MorphoSys; Celgene; Sanofi; Deutsches Krebsforschungszentrum; Bristol-Myers Squibb; Novartis Pharma; Roche; Chugai Pharmaceutical; Amgen","keywords":"Lenalidomide; Medicine; Multiple myeloma; Bortezomib; Maintenance therapy; Clinical endpoint; Internal medicine; Oncology; Dexamethasone; Surgery; Randomized controlled trial; Chemotherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009787129,0.000183282,0.0006492597,0.0001515189,0.00005276572,0.00001776404,0.00007583515,0.00006687895,0.00005581732],"category_scores_gemma":[0.0008278063,0.00008918451,0.00008202788,0.0002138152,0.0001831197,0.0001268176,0.00003615534,0.0001783397,0.000001105137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001602498,"about_ca_system_score_gemma":0.0001475337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006168954,"about_ca_topic_score_gemma":0.0004510899,"domain_scores_codex":[0.9977026,0.0008831491,0.0004849885,0.0002811182,0.0004334861,0.0002146297],"domain_scores_gemma":[0.9972108,0.002092563,0.0003209827,0.0002411834,0.00008327176,0.00005119581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.932864,0.0003851892,0.06021171,0.0000825318,0.0001319961,0.000003173597,0.0005716036,0.00007777384,0.0007205334,0.00003379041,0.00001569689,0.004902052],"study_design_scores_gemma":[0.8678138,0.002144235,0.1251871,0.0005887253,0.00008566929,0.000001012044,0.00004457841,0.001909974,0.002126427,0.000009747877,0.00001175788,0.00007707433],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859604,0.0001071962,0.0001135584,0.0001264193,0.0001464231,0.01348843,0.00002026142,0.000005100203,0.00003218469],"genre_scores_gemma":[0.9984324,0.00005533837,0.00011775,0.00004015647,0.00006586656,0.001203286,0.0000194743,0.00001665298,0.00004910669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06505021,"threshold_uncertainty_score":0.3636839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02388272025755686,"score_gpt":0.3073506523200687,"score_spread":0.2834679320625119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}