{"id":"W2947234519","doi":"10.1200/jco.2021.39.15_suppl.2004","title":"EORTC 1709/CCTG CE.8: A phase III trial of marizomib in combination with temozolomide-based radiochemotherapy versus temozolomide-based radiochemotherapy alone in patients with newly diagnosed glioblastoma.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Queen's University; McMaster University; Hôpital Notre-Dame; Health Sciences Centre; Juravinski Cancer Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Temozolomide; Medicine; Internal medicine; Oncology; Dacarbazine; Concomitant; Interim analysis; Radiation therapy; Chemotherapy; Phases of clinical research; Progression-free survival; Randomized controlled trial; Clinical trial; Glioma; Chemoradiotherapy; Chemotherapy regimen; Quality of life (healthcare); Surgery; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002082427,0.001855497,0.001804853,0.0008119874,0.0005354921,0.0008453208,0.001249958,0.001967357,0.007258554],"category_scores_gemma":[0.001567517,0.0006807697,0.001193071,0.0007323602,0.0009153151,0.000737985,0.0003258401,0.003435311,0.001315695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00213232,"about_ca_system_score_gemma":0.003481958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005725749,"about_ca_topic_score_gemma":0.02278276,"domain_scores_codex":[0.9994579,0.0002853899,0.00002915397,0.00006594241,0.00006287855,0.00009867176],"domain_scores_gemma":[0.9993342,0.0001022716,0.0001906887,0.00002937165,0.00005501326,0.0002883855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9163746,0.01579635,0.001968435,0.001545754,0.0008002495,0.0001505513,0.0001069122,0.0009027324,0.009883012,0.0003945254,0.0115025,0.04057445],"study_design_scores_gemma":[0.9404096,0.05326546,0.002655978,0.00006637469,0.0003081429,0.0000772065,0.00001805433,0.0003732418,0.0005717855,0.0001380188,0.002098991,0.00001718786],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.935941,0.01067034,0.0009733326,0.003347754,0.001063057,0.02829316,0.008703805,0.0004182763,0.01058922],"genre_scores_gemma":[0.9444349,0.006437253,0.003936994,0.005288929,0.000703469,0.02060674,0.008029418,0.0001284579,0.01043382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007258554,"threshold_uncertainty_score":0.02428234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03694737922488343,"score_gpt":0.378806078346372,"score_spread":0.3418586991214885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}