{"id":"W2947261505","doi":"10.1200/jco.2019.37.15_suppl.e14245","title":"Early response assessment through multiparametric MRI based endpoints in a phase II multicenter study evaluating the efficacy of DPX-Survivac, intermittent low dose cyclophosphamide (CPA) and pembrolizumab combination study in subjects with solid tumors.","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"","keywords":"Medicine; Pembrolizumab; Response Evaluation Criteria in Solid Tumors; Target lesion; Radiology; Cancer; Oncology; Clinical trial; Immunotherapy; Phases of clinical research; Internal medicine; Nuclear medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003942587,0.001137968,0.001239127,0.0003141659,0.0002987387,0.0007407057,0.0006138682,0.00106388,0.001479005],"category_scores_gemma":[0.0015042,0.0004239316,0.0008374095,0.0002849651,0.0004479845,0.0006024879,0.0003388056,0.001525361,0.0004895465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005368489,"about_ca_system_score_gemma":0.0008477019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003445402,"about_ca_topic_score_gemma":0.0006552737,"domain_scores_codex":[0.9990151,0.0006603006,0.00003712405,0.0001099077,0.00008224737,0.00009520864],"domain_scores_gemma":[0.9985645,0.0002367316,0.0004229194,0.00009773816,0.0001097862,0.000568323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7762796,0.04989087,0.07321303,0.0003343431,0.001576291,0.0002406693,0.0003319455,0.001958876,0.03778803,0.0001046806,0.001462366,0.05681928],"study_design_scores_gemma":[0.1821103,0.6423317,0.1651179,0.00002424323,0.0007202828,0.0003382454,0.00007525489,0.001918203,0.005305534,0.00009921339,0.001919745,0.00003941625],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974028,0.0005093047,0.0002870519,0.00009831781,0.00001678305,0.0009700548,0.0003340407,0.00002440863,0.0003572172],"genre_scores_gemma":[0.9960306,0.0001987454,0.0008474429,0.0001753703,0.00005212546,0.001466063,0.0007219832,0.000009143013,0.0004984169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003942587,"threshold_uncertainty_score":0.02085066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09063345437569931,"score_gpt":0.4928565972701547,"score_spread":0.4022231428944554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}