{"id":"W2947265946","doi":"10.1200/jco.2019.37.15_suppl.2507","title":"Phase Ib study of MIW815 (ADU-S100) in combination with spartalizumab (PDR001) in patients (pts) with advanced/metastatic solid tumors or lymphomas.","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Nivolumab; Pharmacodynamics; Pharmacokinetics; Lymphoma; Gastroenterology; Oncology; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006614869,0.0009854523,0.001099565,0.0003539206,0.0002601765,0.0006651331,0.0005590139,0.0007567065,0.002391681],"category_scores_gemma":[0.0003881577,0.0003977891,0.0006627053,0.0003383284,0.0005458632,0.0005003015,0.0002631199,0.001849817,0.0008505678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007365019,"about_ca_system_score_gemma":0.0008379319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008522353,"about_ca_topic_score_gemma":0.001360924,"domain_scores_codex":[0.9997836,0.00008923996,0.00001216849,0.00003163121,0.00002053423,0.00006292651],"domain_scores_gemma":[0.9997349,0.00004354097,0.00005253061,0.00002087444,0.00001342767,0.0001346583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4562687,0.1021621,0.01837417,0.001051338,0.001276632,0.00101393,0.000672338,0.006136314,0.1689987,0.0006330661,0.006395308,0.2370175],"study_design_scores_gemma":[0.1890362,0.7611361,0.02030594,0.00004648748,0.0004728681,0.0008162321,0.0001109383,0.002362999,0.01954912,0.0001974519,0.005938824,0.00002678472],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947938,0.001373068,0.0004154313,0.0002247721,0.00006175046,0.0009535557,0.0003710438,0.00007996608,0.001726549],"genre_scores_gemma":[0.9945872,0.0008856232,0.0007359794,0.0002984673,0.00007611391,0.000717046,0.001025572,0.000014137,0.001659932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002391681,"threshold_uncertainty_score":0.00800091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06145907686833232,"score_gpt":0.4461295254891137,"score_spread":0.3846704486207814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}