{"id":"W2947268790","doi":"10.3389/fneur.2019.00524","title":"Subtypes of Alzheimer's Disease Display Distinct Network Abnormalities Extending Beyond Their Pattern of Brain Atrophy","year":2019,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; First Hospital of Jilin University; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Karolinska Institutet; Alzheimerfonden; Servier; IXICO; Jilin University; Vetenskapsrådet; Eisai; H. Lundbeck A/S; Stiftelsen Olle Engkvist Byggmästare; Genentech; Stiftelsen för Strategisk Forskning; Hjärnfonden; F. Hoffmann-La Roche; Pfizer; BioClinica; Biogen; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Demensfonden; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer's Association; Åke Wiberg Stiftelse","keywords":"Atrophy; Neuroscience; Disease; Medicine; Pathology; Psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001813351,0.0002235687,0.0006433985,0.0002086817,0.00003576603,0.000005260039,0.0001661003,0.00009240901,0.0001238504],"category_scores_gemma":[0.000048798,0.0001800449,0.0001953871,0.0002157484,0.0003117613,0.00008835821,0.0001160608,0.0002342198,0.00001039848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001733151,"about_ca_system_score_gemma":0.0001230762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001072735,"about_ca_topic_score_gemma":0.00001403165,"domain_scores_codex":[0.9981814,0.0002378887,0.0004076119,0.0003701784,0.0002677825,0.0005351118],"domain_scores_gemma":[0.998853,0.0001831978,0.000173986,0.0004718332,0.00005559102,0.0002624134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00234129,0.0002776817,0.9898393,0.0001408894,0.001670351,0.0002628269,0.0001092847,0.00009292702,0.00001712223,0.0001386921,0.002381387,0.002728228],"study_design_scores_gemma":[0.002217663,0.001032519,0.992391,0.0000739947,0.0003848858,0.00001506344,0.00005572536,0.001574639,0.0001340844,0.001558432,0.0004169297,0.0001450981],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980803,0.01635963,0.0001699365,0.0006349245,0.0006225955,0.0006248296,0.000162841,0.00002148497,0.0006007554],"genre_scores_gemma":[0.9990014,0.000182599,0.0001156145,0.000364498,0.0001108775,0.00003058464,0.000126664,0.00003575084,0.00003194206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01819847,"threshold_uncertainty_score":0.7342016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103258033728785,"score_gpt":0.2568165062550158,"score_spread":0.2457839259177279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}