{"id":"W2947268790","doi":"10.3389/fneur.2019.00524","title":"Subtypes of Alzheimer's Disease Display Distinct Network Abnormalities Extending Beyond Their Pattern of Brain Atrophy","year":2019,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; First Hospital of Jilin University; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Karolinska Institutet; Alzheimerfonden; Servier; IXICO; Jilin University; Vetenskapsrådet; Eisai; H. Lundbeck A/S; Stiftelsen Olle Engkvist Byggmästare; Genentech; Stiftelsen för Strategisk Forskning; Hjärnfonden; F. Hoffmann-La Roche; Pfizer; BioClinica; Biogen; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Demensfonden; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer's Association; Åke Wiberg Stiftelse","keywords":"Atrophy; Neuroscience; Disease; Medicine; Pathology; Psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001597681,0.0003068963,0.0002564515,0.001192504,0.0002228107,0.0003110387,0.00017951,0.0001825615,0.0004498726],"category_scores_gemma":[0.0008720438,0.00014188,0.0002718533,0.000568467,0.0002908555,0.0002845953,0.0002490589,0.0001356581,0.0001203564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002172892,"about_ca_system_score_gemma":0.0001088256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003573836,"about_ca_topic_score_gemma":0.009018621,"domain_scores_codex":[0.9998746,0.00002366608,0.00001401409,0.00004002101,0.00002994267,0.00001766611],"domain_scores_gemma":[0.9996279,0.00008277395,0.000175867,0.00005217123,0.00003498651,0.00002620134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004638929,0.00006151642,0.9333832,0.00009259534,0.0004387917,0.0004096914,0.0007090555,0.00230729,0.02404969,0.0007242322,0.0003421887,0.0370178],"study_design_scores_gemma":[0.000008151777,0.00005987376,0.9944358,0.000005278273,0.00006270517,0.0007744107,0.000160197,0.001896898,0.0006683928,0.001634755,0.0002882098,0.000005421768],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983418,0.0001960064,0.0008391028,0.00001271296,0.000001263507,0.00001024997,0.0001269488,0.00001631026,0.0004556081],"genre_scores_gemma":[0.9986556,0.00008765592,0.0008088626,0.000005963195,0.000002604541,0.000006251759,0.0003135375,0.000002824766,0.0001166585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003573836,"threshold_uncertainty_score":0.007106066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103258033728785,"score_gpt":0.2568165062550158,"score_spread":0.2457839259177279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}