{"id":"W2947332782","doi":"10.1002/etc.4385","title":"Adverse Outcome Pathways: Moving from a Scientific Concept to an Internationally Accepted Framework","year":2019,"lang":"en","type":"article","venue":"Environmental Toxicology and Chemistry","topic":"Animal testing and alternatives","field":"Veterinary","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Joint Research Centre; Canada Research Chairs; European Commission; Humane Society International; U.S. Army Corps of Engineers; Society of Environmental Toxicology and Chemistry; European Chemical Industry Council; Office of Research and Development; U.S. Environmental Protection Agency","keywords":"Adverse Outcome Pathway; Authorization; European union; Risk analysis (engineering); Population; Computer science; Business; Medicine; Biology; Computer security; Environmental health; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1242285,0.004787887,0.003661319,0.0130853,0.005911943,0.02902358,0.01301183,0.01427973,0.007241445],"category_scores_gemma":[0.08230875,0.001320023,0.003782587,0.006198216,0.06124232,0.04054623,0.01859679,0.03064726,0.001543815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02128729,"about_ca_system_score_gemma":0.04037492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008143128,"about_ca_topic_score_gemma":0.004209839,"domain_scores_codex":[0.9445825,0.02912713,0.004992441,0.007076417,0.01239201,0.001829516],"domain_scores_gemma":[0.8620702,0.0923545,0.009721097,0.006279431,0.02391014,0.005664606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00003276788,0.00005123239,0.0005189499,0.0008295319,0.00003276413,0.0001519679,0.0008876777,0.001599383,0.0001337709,0.9674643,0.004862297,0.02343532],"study_design_scores_gemma":[0.00001903392,0.00008389321,0.0003403764,0.001768372,0.00004470636,0.0001698668,0.001455008,0.001651475,0.0002088163,0.9195768,0.07463023,0.00005145882],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.003844904,0.07477906,0.5659307,0.2917091,0.008361839,0.0009215342,0.0007004915,0.0005008775,0.05325142],"genre_scores_gemma":[0.2140692,0.1652316,0.4931142,0.08696159,0.02169706,0.005037404,0.001664999,0.0006546272,0.01156924],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.1242285,"threshold_uncertainty_score":0.6569908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06406199960035136,"score_gpt":0.3322493863823798,"score_spread":0.2681873867820285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}