{"id":"W2947335069","doi":"10.1101/651463","title":"Genetically encoded intrabody sensors illuminate structural and functional diversity in GPCR-β-arrestin complexes","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Biotechnology and Biological Sciences Research Council","keywords":"G protein-coupled receptor; Arrestin; Receptor; Context (archaeology); Signal transduction; Functional selectivity; Phosphorylation; Biology; Functional diversity; Computational biology; Cell biology; Neuroscience; Biochemistry; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473563,0.0002047756,0.0001716172,0.00016558,0.00009137664,0.0003455557,0.0001657128,0.0003083451,0.0009400473],"category_scores_gemma":[0.00009411896,0.0001196594,0.000110332,0.00007640774,0.0003079708,0.0002209286,0.0003400054,0.0005326805,0.0003624162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000249339,"about_ca_system_score_gemma":0.00006789872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001302756,"about_ca_topic_score_gemma":0.0001855222,"domain_scores_codex":[0.9999028,0.00001356837,0.000005577142,0.00002936489,0.00002916492,0.00001935507],"domain_scores_gemma":[0.9999397,0.00001357027,0.00001967308,0.00000943841,0.000005908998,0.00001162895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001323807,0.000004135563,0.00005754328,0.000007532244,0.000001287303,0.00001853601,0.000005778367,0.00007929515,0.9991465,0.0003415176,0.00002863831,0.0002960223],"study_design_scores_gemma":[0.000004660304,0.00002510178,0.0008207015,0.000001735015,0.000002675968,0.00008255751,0.00001012504,0.002888202,0.9945839,0.0001881639,0.00138904,0.00000318213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750596,0.0005472404,0.02060316,0.00025509,0.00004414066,0.00001391939,0.0002150767,0.0002109865,0.003050796],"genre_scores_gemma":[0.9865772,0.000314694,0.009633388,0.00008074353,0.0000106703,0.0000144003,0.0001963671,0.00009051682,0.00308211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009400473,"threshold_uncertainty_score":0.003144801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01421462483699922,"score_gpt":0.2100829934962132,"score_spread":0.1958683686592139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}