{"id":"W2947343430","doi":"10.1097/j.pain.0000000000001624","title":"DNA methylation profiles are associated with complex regional pain syndrome after traumatic injury","year":2019,"lang":"en","type":"article","venue":"Pain","topic":"Pain Management and Treatment","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences","keywords":"DNA methylation; Epigenetics; Complex regional pain syndrome; Immune system; FKBP5; Neuroimmunology; Gene; CpG site; Biology; Medicine; Genetics; Bioinformatics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001945653,0.0001015896,0.0001711611,0.0004438378,0.0001136087,0.0001751156,0.0001217956,0.0001848314,0.0008191722],"category_scores_gemma":[0.00114298,0.00007002251,0.0001295177,0.0003689848,0.0001571808,0.0000958235,0.0002206737,0.0001658059,0.00009224522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001157827,"about_ca_system_score_gemma":0.00007553312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350912,"about_ca_topic_score_gemma":0.001741353,"domain_scores_codex":[0.9998276,0.00004450463,0.00001615997,0.00004676953,0.00003677489,0.00002799371],"domain_scores_gemma":[0.999479,0.0001077644,0.0003006607,0.00002548723,0.00004688485,0.00004019371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000623823,0.00003753549,0.9369894,0.00005960866,0.0001668772,0.0002106945,0.0002469758,0.000137505,0.04804332,0.00004316293,0.00007866693,0.01336246],"study_design_scores_gemma":[0.000002351601,0.00006345675,0.998755,0.000002299421,0.00001872682,0.000248858,0.00004951679,0.0001678744,0.0006114609,0.00002790677,0.00005069486,0.000001828289],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992705,0.0002358674,0.0002317522,0.00002148821,0.000001264948,0.000003319557,0.00009608733,0.000003551956,0.0001361901],"genre_scores_gemma":[0.9995772,0.0001027853,0.000117953,0.000009879254,0.000002733696,0.000003619978,0.00008386522,0.000001000043,0.0001008988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350912,"threshold_uncertainty_score":0.002740443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02910033889831641,"score_gpt":0.2590113166714895,"score_spread":0.2299109777731731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}