{"id":"W2947348388","doi":"10.26508/lsa.201900303","title":"Rate of brain aging and <i>APOE ε4</i> are synergistic risk factors for Alzheimer’s disease","year":2019,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mental Health Research Canada; University of Toronto","funders":"Fondation pour la Recherche Médicale; National Institute on Aging; Glenn Foundation for Medical Research; American Federation for Aging Research; Ellison Medical Foundation","keywords":"Apolipoprotein E; Disease; Dementia; Cognitive decline; Aging brain; Cognitive aging; Cohort; Ageing; Medicine; Cognition; Alzheimer's disease; Internal medicine; Gerontology; Psychology; Oncology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005318066,0.0001803245,0.0002152129,0.0004503293,0.0001931693,0.0003762035,0.0001418714,0.0001569789,0.0007866304],"category_scores_gemma":[0.0008471334,0.0001230659,0.0001810818,0.0002686987,0.000241062,0.0001980406,0.0003228967,0.0003335671,0.0001456137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001589352,"about_ca_system_score_gemma":0.0001633148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001513421,"about_ca_topic_score_gemma":0.002399274,"domain_scores_codex":[0.9998187,0.00005209546,0.0000124569,0.00005257731,0.00004172326,0.00002239996],"domain_scores_gemma":[0.9994259,0.00005963531,0.0002991415,0.0000881726,0.00006667268,0.00006043946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009457576,0.0001014614,0.9070944,0.00003834785,0.0001808159,0.0001200756,0.0004053274,0.0002470676,0.06883663,0.0003765991,0.000319205,0.02133431],"study_design_scores_gemma":[0.000004129495,0.0001129385,0.9946972,0.000004526492,0.00003486723,0.000153256,0.0000791701,0.0001612872,0.004210722,0.0001708553,0.0003659082,0.000005044724],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980581,0.0002724174,0.0005385395,0.00004856146,0.000006396437,0.000005685171,0.0001741884,0.00001173497,0.0008843851],"genre_scores_gemma":[0.998609,0.0001707245,0.0006167227,0.0000272338,0.000008687171,0.000008683526,0.000170207,0.000004177223,0.0003845705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001513421,"threshold_uncertainty_score":0.0030092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03213828333733927,"score_gpt":0.3353015879946227,"score_spread":0.3031633046572835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}