{"id":"W2947348388","doi":"10.26508/lsa.201900303","title":"Rate of brain aging and <i>APOE ε4</i> are synergistic risk factors for Alzheimer’s disease","year":2019,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mental Health Research Canada; University of Toronto","funders":"Fondation pour la Recherche Médicale; National Institute on Aging; Glenn Foundation for Medical Research; American Federation for Aging Research; Ellison Medical Foundation","keywords":"Apolipoprotein E; Disease; Dementia; Cognitive decline; Aging brain; Cognitive aging; Cohort; Ageing; Medicine; Cognition; Alzheimer's disease; Internal medicine; Gerontology; Psychology; Oncology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007633404,0.000113156,0.0002044895,0.00007637908,0.000138216,0.00004493995,0.0001796584,0.00001853082,0.00007154068],"category_scores_gemma":[0.001471978,0.00008944033,0.00005446955,0.0003707306,0.0004915656,0.0002442621,0.00007756717,0.00009260193,0.00001797426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001691181,"about_ca_system_score_gemma":0.0002885153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002617552,"about_ca_topic_score_gemma":0.000002145687,"domain_scores_codex":[0.9985979,0.00003599841,0.0001745109,0.0004102287,0.0003916819,0.0003896953],"domain_scores_gemma":[0.9986914,0.0003029314,0.0001303822,0.0002485067,0.0002133037,0.0004134608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000125445,0.00007030094,0.9843736,0.0001435232,0.00002995367,0.000004815979,0.0001048907,0.00001436627,0.01322594,0.0002417396,0.0004879365,0.001177502],"study_design_scores_gemma":[0.001034094,0.0002313101,0.9802369,0.0002362206,0.0001024951,4.847641e-7,0.0003876325,0.002541286,0.01346993,0.0002842417,0.001349828,0.0001255725],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958739,0.0007307153,0.0004969991,0.001611851,0.0001244881,0.0007332614,0.00005321987,0.00001853917,0.0003570827],"genre_scores_gemma":[0.9976532,0.000126737,0.000213917,0.0009097104,0.00003878354,0.00002597068,0.000006344872,0.000009612318,0.001015733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00413669,"threshold_uncertainty_score":0.3647271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03213828333733927,"score_gpt":0.3353015879946227,"score_spread":0.3031633046572835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}