{"id":"W2947364881","doi":"10.1093/neuonc/noz126.006","title":"PL3.3 Second interim and first molecular analysis of the EORTC randomized phase III intergroup CATNON trial on concurrent and adjuvant temozolomide in anaplastic glioma without 1p/19q codeletion","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Temozolomide; Glioma; Isocitrate dehydrogenase; Medicine; Internal medicine; Interim analysis; Hazard ratio; Oncology; IDH1; Univariate analysis; Randomized controlled trial; Confidence interval; Radiation therapy; Cancer research; Biology; Multivariate analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004835507,0.001029514,0.001569679,0.0002909759,0.000296151,0.0009147697,0.0005332819,0.000822796,0.00534923],"category_scores_gemma":[0.002767739,0.0003651177,0.002125395,0.0003181697,0.0006021119,0.0006595156,0.0004806551,0.001929744,0.0006293581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001087856,"about_ca_system_score_gemma":0.001561722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005866351,"about_ca_topic_score_gemma":0.001832554,"domain_scores_codex":[0.9980333,0.001337206,0.00006869365,0.000233444,0.0001562094,0.0001711149],"domain_scores_gemma":[0.9984585,0.0004385611,0.000402277,0.0002130172,0.0001336648,0.0003539361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9594471,0.002001016,0.004435777,0.0004241761,0.002001961,0.00006272621,0.00004359627,0.001575395,0.007298833,0.0004334862,0.004230871,0.01804509],"study_design_scores_gemma":[0.7584471,0.182205,0.03385895,0.0001011542,0.004014664,0.0001874416,0.00005350359,0.003899086,0.005613519,0.001582326,0.009973763,0.00006347367],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738307,0.003568171,0.003066153,0.001430361,0.0006139363,0.003896606,0.007528025,0.0002063072,0.005859771],"genre_scores_gemma":[0.9734536,0.0006995602,0.0033986,0.001295554,0.0002028797,0.006244946,0.009034029,0.00009793803,0.005572864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00534923,"threshold_uncertainty_score":0.0255729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400393742583586,"score_gpt":0.3095707283575078,"score_spread":0.2955667909316719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}