{"id":"W2947388337","doi":"10.1038/s41380-019-0463-8","title":"A polygenic resilience score moderates the genetic risk for schizophrenia","year":2019,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Research and Development; National Institute of Mental Health; Russian Academy of Sciences; Stanley Center for Psychiatric Research, Broad Institute; Campbell Family Mental Health Research Institute; University of Colorado Denver; National Institutes of Health; Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; Pécsi Tudományegyetem; Fujita Health University; Universitätsklinikum Jena; Medizinische Universität Wien; University of Colorado Boulder; Universität Regensburg; Genome Institute of Singapore; Johns Hopkins University; Universitetet i Oslo; Eli Lilly and Company; Danmarks Tekniske Universitet; Sichuan University; Johns Hopkins Bloomberg School of Public Health; Universitetet i Bergen; Univerzita Karlova v Praze; Samfundet Folkhälsan; National Institute on Aging; University of Hong Kong; Statens Serum Institut; Universität Heidelberg; Universiteit van Amsterdam; Department of Psychiatry, Columbia University; Universität Wien; Queensland Brain Institute; Karolinska Institutet; University of Queensland; Rijksuniversiteit Groningen; Sidney R. Baer, Jr. Foundation; Institut National de la Santé et de la Recherche Médicale; Trinity College Dublin; University College Cork; Pomorski Uniwersytet Medyczny W Szczecinie; Vrije Universiteit Amsterdam; University of Oxford; Medical Research Council; Tartu Ülikool; University of Galway; Broad Institute; University of Southern California; Universidad de Cantabria; Wellcome Trust; Lundbeckfonden; University College London; Royal College of Surgeons in Ireland; European Commission; NorthShore University HealthSystem; National Institute on Alcohol Abuse and Alcoholism; Universiteit Maastricht; National University of Ireland; West China Hospital, Sichuan University; London School of Hygiene and Tropical Medicine; Hebrew University of Jerusalem; Terveyden ja hyvinvoinnin laitos; Centre National de la Recherche Scientifique; King's College London; Virginia Commonwealth University; F. Hoffmann-La Roche; University of North Carolina at Chapel Hill; Harvard University; National Institute for Health and Care Research; Massachusetts General Hospital; University of California, Los Angeles; Pfizer; Universität Basel; National Alliance for Research on Schizophrenia and Depression; Cardiff University; Rheinische Friedrich-Wilhelms-Universität Bonn; Universitair Medisch Centrum Groningen; U.S. Department of Health and Human Services","keywords":"Polygenic risk score; Schizophrenia (object-oriented programming); Construct (python library); Genome-wide association study; Genetic architecture; Genetics; Allele; Multifactorial Inheritance; Genomics; Psychology; Biology; Quantitative trait locus; Psychiatry; Single-nucleotide polymorphism; Genome; Gene; Genotype; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007560955,0.0006279608,0.0002314285,0.001163045,0.0004910844,0.0006256358,0.0002217787,0.0004257232,0.00229202],"category_scores_gemma":[0.002889435,0.0002569515,0.0004630381,0.0006540427,0.0005671613,0.0002813889,0.001025136,0.0005851555,0.0001295295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002686757,"about_ca_system_score_gemma":0.0003893243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004891564,"about_ca_topic_score_gemma":0.006583937,"domain_scores_codex":[0.9994931,0.0001990081,0.00004217819,0.0001310699,0.00007243414,0.00006220385],"domain_scores_gemma":[0.9988445,0.0002403839,0.0005419711,0.000111626,0.00004821825,0.0002131656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008908809,0.000133912,0.9786215,0.00001949272,0.0004709745,0.0002267919,0.0002641862,0.0006124053,0.01124686,0.0005926883,0.0001385314,0.006781683],"study_design_scores_gemma":[0.00001075933,0.0001344679,0.9968394,0.000006512997,0.0001205454,0.000214964,0.00009605507,0.00134359,0.0006018861,0.0005259876,0.00009654632,0.0000094058],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999229,0.00003176904,0.0003441129,0.00004485103,0.000003127992,0.000004464148,0.00006796391,0.000008302472,0.000266581],"genre_scores_gemma":[0.9994215,0.00002749499,0.0003780531,0.000008193757,0.000002885037,0.000003050771,0.00005805992,0.000002646298,0.00009833564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004891564,"threshold_uncertainty_score":0.009726226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005262632452362852,"score_gpt":0.2370753276111452,"score_spread":0.2318126951587824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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