{"id":"W2947388337","doi":"10.1038/s41380-019-0463-8","title":"A polygenic resilience score moderates the genetic risk for schizophrenia","year":2019,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Research and Development; National Institute of Mental Health; Russian Academy of Sciences; Stanley Center for Psychiatric Research, Broad Institute; Campbell Family Mental Health Research Institute; University of Colorado Denver; National Institutes of Health; Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; Pécsi Tudományegyetem; Fujita Health University; Universitätsklinikum Jena; Medizinische Universität Wien; University of Colorado Boulder; Universität Regensburg; Genome Institute of Singapore; Johns Hopkins University; Universitetet i Oslo; Eli Lilly and Company; Danmarks Tekniske Universitet; Sichuan University; Johns Hopkins Bloomberg School of Public Health; Universitetet i Bergen; Univerzita Karlova v Praze; Samfundet Folkhälsan; National Institute on Aging; University of Hong Kong; Statens Serum Institut; Universität Heidelberg; Universiteit van Amsterdam; Department of Psychiatry, Columbia University; Universität Wien; Queensland Brain Institute; Karolinska Institutet; University of Queensland; Rijksuniversiteit Groningen; Sidney R. Baer, Jr. Foundation; Institut National de la Santé et de la Recherche Médicale; Trinity College Dublin; University College Cork; Pomorski Uniwersytet Medyczny W Szczecinie; Vrije Universiteit Amsterdam; University of Oxford; Medical Research Council; Tartu Ülikool; University of Galway; Broad Institute; University of Southern California; Universidad de Cantabria; Wellcome Trust; Lundbeckfonden; University College London; Royal College of Surgeons in Ireland; European Commission; NorthShore University HealthSystem; National Institute on Alcohol Abuse and Alcoholism; Universiteit Maastricht; National University of Ireland; West China Hospital, Sichuan University; London School of Hygiene and Tropical Medicine; Hebrew University of Jerusalem; Terveyden ja hyvinvoinnin laitos; Centre National de la Recherche Scientifique; King's College London; Virginia Commonwealth University; F. Hoffmann-La Roche; University of North Carolina at Chapel Hill; Harvard University; National Institute for Health and Care Research; Massachusetts General Hospital; University of California, Los Angeles; Pfizer; Universität Basel; National Alliance for Research on Schizophrenia and Depression; Cardiff University; Rheinische Friedrich-Wilhelms-Universität Bonn; Universitair Medisch Centrum Groningen; U.S. Department of Health and Human Services","keywords":"Polygenic risk score; Schizophrenia (object-oriented programming); Construct (python library); Genome-wide association study; Genetic architecture; Genetics; Allele; Multifactorial Inheritance; Genomics; Psychology; Biology; Quantitative trait locus; Psychiatry; Single-nucleotide polymorphism; Genome; Gene; Genotype; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003160009,0.0002004075,0.0001837133,0.00003522258,0.000205906,0.000030626,0.0003979031,0.0001675134,0.00001916623],"category_scores_gemma":[0.0001438912,0.0001550579,0.0002340495,0.0001163284,0.00007236517,0.000002159513,0.00009632411,0.0001365348,0.00005592785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001041406,"about_ca_system_score_gemma":0.0001781358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003014095,"about_ca_topic_score_gemma":0.00006813991,"domain_scores_codex":[0.9985098,0.0001662683,0.0002934867,0.0005163241,0.0001163598,0.0003977805],"domain_scores_gemma":[0.9988797,0.00003288447,0.0001792916,0.0007547552,0.00008263162,0.00007076575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003902023,0.0001440398,0.791293,0.00004363587,0.0003995186,0.000001226989,0.00005783133,0.01744538,0.1681966,0.002661059,0.0153958,0.00397167],"study_design_scores_gemma":[0.004100134,0.001574666,0.9224945,0.00004390926,0.0002882248,0.0000731761,0.0003112366,0.01340041,0.009772633,0.02894942,0.01780308,0.001188629],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625847,0.004891307,0.02969905,0.001171129,0.0006219161,0.0006250525,0.00003880984,0.00001528838,0.0003527186],"genre_scores_gemma":[0.976975,0.0001643203,0.02057528,0.001314602,0.0002331449,0.0001128666,0.00005579695,0.00003821854,0.0005307422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.158424,"threshold_uncertainty_score":0.6323077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005262632452362852,"score_gpt":0.2370753276111452,"score_spread":0.2318126951587824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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