{"id":"W2947388394","doi":"10.1200/jco.2019.37.15_suppl.2009","title":"NRG Oncology CC001: A phase III trial of hippocampal avoidance (HA) in addition to whole-brain radiotherapy (WBRT) plus memantine to preserve neurocognitive function (NCF) in patients with brain metastases (BM).","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer-related cognitive impairment studies","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan; Hôtel-Dieu de Montréal","funders":"","keywords":"Medicine; Hazard ratio; Neurocognitive; Internal medicine; Clinical endpoint; Randomized controlled trial; Cumulative incidence; Radiosurgery; Oncology; Radiation therapy; Confidence interval; Surgery; Cohort; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001080785,0.0013047,0.001138623,0.0004258291,0.0002712601,0.000458577,0.0009703342,0.000738354,0.004692562],"category_scores_gemma":[0.0006175319,0.0002859805,0.0009308618,0.0004336063,0.000773267,0.000416474,0.00027035,0.001928303,0.000762783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001129707,"about_ca_system_score_gemma":0.00164445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00234773,"about_ca_topic_score_gemma":0.009441679,"domain_scores_codex":[0.9997489,0.00012514,0.00001033354,0.00003957853,0.00002780685,0.00004830164],"domain_scores_gemma":[0.9995759,0.0000694669,0.000104899,0.00003305241,0.00002001097,0.0001966603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7882326,0.034246,0.009548161,0.00126222,0.001850734,0.0002113769,0.0002137697,0.002274005,0.02337566,0.0004839661,0.008085868,0.1302157],"study_design_scores_gemma":[0.6454839,0.3299341,0.01609364,0.00008475513,0.000815175,0.0002959198,0.00004948322,0.0009074425,0.002844665,0.0002095072,0.003249638,0.00003171719],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923425,0.002820924,0.0002787157,0.0005232537,0.0001200115,0.0012374,0.0009305126,0.00009128922,0.001655425],"genre_scores_gemma":[0.9890525,0.002421654,0.001272331,0.0008467396,0.0002015801,0.001633039,0.001727934,0.00002555662,0.002818652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004692562,"threshold_uncertainty_score":0.01569813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0558983452086749,"score_gpt":0.435088852145244,"score_spread":0.3791905069365691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}