{"id":"W2947417651","doi":"10.1200/jco.2019.37.15_suppl.e17068","title":"Increasing potency and safety of anticancer drugs through sortilin receptor-mediated cancer therapy: A new targeted approach for the treatment of ovarian cancer.","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Ovarian cancer; Doxorubicin; Cancer research; Cancer cell; Peptide; Cancer; Medicine; Pharmacology; Receptor; Cell culture; Biology; Internal medicine; Biochemistry; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002832334,0.0003071958,0.0002800683,0.0003063549,0.00007846325,0.0003777427,0.0002444849,0.0004591842,0.001622013],"category_scores_gemma":[0.00009025473,0.000115396,0.0002665147,0.0002172008,0.0002187454,0.0004169513,0.0002342854,0.0004684446,0.0004486225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003667318,"about_ca_system_score_gemma":0.0003213838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001815548,"about_ca_topic_score_gemma":0.0004377163,"domain_scores_codex":[0.9999307,0.00001461414,0.000004804722,0.000009734301,0.00002717939,0.00001300552],"domain_scores_gemma":[0.9999498,0.00000872182,0.00002064343,0.000003135008,0.000007823655,0.000009793589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009703736,0.0001764318,0.001409076,0.001192847,0.00007807594,0.0007734821,0.00004838899,0.0006465006,0.8324096,0.004079537,0.004096056,0.1541196],"study_design_scores_gemma":[0.0008927501,0.002922002,0.01045245,0.0001310773,0.0003301631,0.01038254,0.0001138948,0.007651435,0.7586189,0.001635681,0.2068185,0.00005057453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6951641,0.2372938,0.03828074,0.008841235,0.0007666483,0.000451953,0.0009301649,0.0006420222,0.01762924],"genre_scores_gemma":[0.8835409,0.09171943,0.01227361,0.001423278,0.0001956573,0.0001710169,0.0006826032,0.00003873278,0.009954667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001622013,"threshold_uncertainty_score":0.005426228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07427144066241295,"score_gpt":0.4406020321628589,"score_spread":0.3663305915004459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}