{"id":"W2947459626","doi":"10.1186/s13063-019-3391-7","title":"RTS,S malaria vaccine pilot studies: addressing the human realities in large-scale clinical trials","year":2019,"lang":"en","type":"letter","venue":"Trials","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"International Development Research Centre; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Malaria; Malaria vaccine; Medicine; Clinical trial; Public health; Community engagement; Intervention (counseling); Clinical research; Scale (ratio); Alternative medicine; Environmental health; Nursing; Public relations; Immunology; Political science; Plasmodium falciparum; Geography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.08463044,0.000573651,0.006420384,0.0004610567,0.0003438373,0.0001951592,0.000406255,0.001165323,0.001965898],"category_scores_gemma":[0.02908848,0.0003146418,0.001282822,0.0004430875,0.0001933906,0.0001146038,0.0003223299,0.004692948,0.0003401573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002496807,"about_ca_system_score_gemma":0.0004291802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006105634,"about_ca_topic_score_gemma":0.0003463476,"domain_scores_codex":[0.9761319,0.01572465,0.005370922,0.0008684953,0.0009500741,0.0009540105],"domain_scores_gemma":[0.9727823,0.02351835,0.001689926,0.001451403,0.000445355,0.0001126673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009236188,0.0002328363,0.001888076,0.0005970044,0.001070864,0.0002084788,0.0002757111,0.000001650762,0.0002623394,0.00007719555,0.9931005,0.001361734],"study_design_scores_gemma":[0.01601891,0.001666995,0.004796747,0.002008817,0.001323877,0.00004564746,0.0007478754,0.00002457828,0.0001484673,0.0006296646,0.97215,0.0004384127],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0189396,0.007610689,0.00004601886,0.9495304,0.005506941,0.0105431,0.000551619,0.0001925733,0.007079052],"genre_scores_gemma":[0.03774532,0.01059132,0.0001960075,0.7029021,0.1189755,0.001592526,0.001918125,0.0004648515,0.1256142],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2466283,"threshold_uncertainty_score":0.9999306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7013817237633211,"score_gpt":0.5987847388453506,"score_spread":0.1025969849179705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}