{"id":"W2947459626","doi":"10.1186/s13063-019-3391-7","title":"RTS,S malaria vaccine pilot studies: addressing the human realities in large-scale clinical trials","year":2019,"lang":"en","type":"letter","venue":"Trials","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"International Development Research Centre; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Malaria; Malaria vaccine; Medicine; Clinical trial; Public health; Community engagement; Intervention (counseling); Clinical research; Scale (ratio); Alternative medicine; Environmental health; Nursing; Public relations; Immunology; Political science; Plasmodium falciparum; Geography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08452712,0.0009434696,0.001759376,0.0008828936,0.006395674,0.008972203,0.004369962,0.06502616,0.005441318],"category_scores_gemma":[0.1762578,0.001201618,0.001645047,0.001399348,0.01027434,0.009099502,0.003645916,0.03395366,0.004503185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00757863,"about_ca_system_score_gemma":0.01669556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003314467,"about_ca_topic_score_gemma":0.009247584,"domain_scores_codex":[0.917652,0.05854031,0.007393488,0.003928604,0.01036508,0.002120505],"domain_scores_gemma":[0.7369553,0.2085248,0.01112109,0.0072941,0.01688625,0.01921837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0006454654,0.0002417526,0.005614686,0.0006103944,0.00009539655,0.01099623,0.002084138,0.0002780266,0.001771574,0.01248928,0.904763,0.06041015],"study_design_scores_gemma":[0.001075602,0.001525953,0.005347564,0.001298656,0.0001208732,0.008664383,0.003732639,0.002116322,0.001154623,0.03605778,0.9387005,0.0002051718],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001017948,0.0007972247,0.0003114189,0.9924562,0.003448102,0.00007747853,0.0000204692,0.00002898847,0.001842177],"genre_scores_gemma":[0.009061457,0.001072453,0.001870331,0.9682761,0.01643499,0.0003717096,0.00001830077,0.00003015998,0.002864538],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.08452712,"threshold_uncertainty_score":0.4470275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7013817237633211,"score_gpt":0.5987847388453506,"score_spread":0.1025969849179705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}