{"id":"W2947489447","doi":"10.1016/j.smim.2019.05.001","title":"Type I interferon signaling, regulation and gene stimulation in chronic virus infection","year":2019,"lang":"en","type":"review","venue":"Seminars in Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":156,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Immune system; Immunology; Interferon; Biology; Signal transduction; Virus; Inflammation; Innate immune system; Viral replication; Chronic infection; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006729073,0.001043714,0.001261262,0.001111032,0.0002367314,0.001046734,0.0008829936,0.001222367,0.002177397],"category_scores_gemma":[0.0004587061,0.0002711373,0.0002623003,0.001482948,0.0006817852,0.001318601,0.0008282397,0.001809475,0.002190683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000662988,"about_ca_system_score_gemma":0.0007648002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004181052,"about_ca_topic_score_gemma":0.0007933351,"domain_scores_codex":[0.999867,0.00001992553,0.00001903348,0.00002284896,0.00005016639,0.00002102708],"domain_scores_gemma":[0.9998437,0.00006704411,0.00002890996,0.000006299751,0.00002734244,0.00002666917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000242512,0.00006924178,0.0001475884,0.01134592,0.00004814914,0.000265083,0.00004549323,0.0003547963,0.006177786,0.005478738,0.05302812,0.9227966],"study_design_scores_gemma":[0.0000378516,0.0001029328,0.00108662,0.00185348,0.00005979408,0.0009938646,0.00004592864,0.0001155391,0.0007352087,0.003678583,0.991273,0.00001726559],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001032834,0.9982793,0.0001311116,0.0002325886,0.0006083749,0.000002527642,0.00001152836,0.00000553676,0.0006257682],"genre_scores_gemma":[0.0006959254,0.9969534,0.0001369356,0.000245471,0.001039025,0.000008005424,0.00002908552,0.000001382399,0.0008908627],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002177397,"threshold_uncertainty_score":0.007284105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03171834405678439,"score_gpt":0.3194975370253142,"score_spread":0.2877791929685298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}