{"id":"W2947563175","doi":"10.3390/cancers11060752","title":"In Vivo Evaluation of Dual-Targeted Nanoparticles Encapsulating Paclitaxel and Everolimus","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Paclitaxel; In vivo; Pharmacology; Everolimus; Pharmacokinetics; Drug delivery; Drug; Medicine; Epidermal growth factor receptor; Toxicity; Chemistry; Chemotherapy; Receptor; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001146338,0.00009023093,0.0001710357,0.00006952172,0.00002631244,0.00001776732,0.00006749163,0.00003956102,0.0009465733],"category_scores_gemma":[0.0001582547,0.00008919658,0.00001993327,0.00020172,0.00007431651,0.0003156812,0.0000375512,0.00004215921,0.00005083287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004504421,"about_ca_system_score_gemma":0.0003244187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006039166,"about_ca_topic_score_gemma":0.00008645639,"domain_scores_codex":[0.998683,0.000155189,0.0002813044,0.000247335,0.0003959796,0.0002371535],"domain_scores_gemma":[0.9994014,0.00009763178,0.0001223672,0.0002036969,0.0001198126,0.00005510921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004280114,0.000008852443,0.00566378,0.00002660002,0.000002834857,0.00000128599,0.0006810998,0.01485432,0.9781228,0.0000835855,0.00007757007,0.0004344481],"study_design_scores_gemma":[0.001185602,0.0000659384,0.00426227,0.00005318503,0.00001991254,0.000001463635,0.0004216406,0.03036592,0.9630876,0.0003972276,0.00003235613,0.0001068542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984156,0.0005524103,0.000002108187,0.00006223199,0.0003304891,0.0003138675,0.0000158559,0.00001994657,0.0002874993],"genre_scores_gemma":[0.9995724,0.000008499314,0.0002360588,0.00008974643,0.00002446023,0.00002485509,6.916312e-7,0.000009939425,0.00003335403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0155116,"threshold_uncertainty_score":0.9999667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02011502941351685,"score_gpt":0.2715310383553518,"score_spread":0.2514160089418349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}