{"id":"W2947563175","doi":"10.3390/cancers11060752","title":"In Vivo Evaluation of Dual-Targeted Nanoparticles Encapsulating Paclitaxel and Everolimus","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Paclitaxel; In vivo; Pharmacology; Everolimus; Pharmacokinetics; Drug delivery; Drug; Medicine; Epidermal growth factor receptor; Toxicity; Chemistry; Chemotherapy; Receptor; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003074255,0.0004145771,0.0003486197,0.0001548087,0.000108208,0.000220361,0.0002147751,0.0004032282,0.0005096863],"category_scores_gemma":[0.0001728697,0.000181452,0.0002365394,0.0001034446,0.0002041677,0.0002630855,0.0001028042,0.0004732607,0.0001444089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000227529,"about_ca_system_score_gemma":0.0001925997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006207432,"about_ca_topic_score_gemma":0.0006879862,"domain_scores_codex":[0.9998759,0.00002927657,0.000008648917,0.00003163666,0.00002779161,0.0000266785],"domain_scores_gemma":[0.9998853,0.00003150566,0.00003297623,0.000009273262,0.0000222905,0.00001859825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003064516,0.0001242271,0.00007177916,0.0000265343,0.000006796761,0.00002775868,0.00001917245,0.0001578185,0.9983217,0.00003195782,0.00002328513,0.000882454],"study_design_scores_gemma":[0.00004595855,0.00304024,0.001709909,0.000003316715,0.00003834513,0.0001112561,0.00001930423,0.004124871,0.9902125,0.00002886292,0.0006595673,0.000005895899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940807,0.0007402344,0.003920449,0.00005281929,0.00003585119,0.00004901907,0.0001408052,0.0000542211,0.0009258368],"genre_scores_gemma":[0.9917424,0.0007999943,0.004729219,0.00004202449,0.00001926723,0.0001279459,0.0002148249,0.00002573773,0.002298599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006207432,"threshold_uncertainty_score":0.00170505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02011502941351685,"score_gpt":0.2715310383553518,"score_spread":0.2514160089418349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}