{"id":"W2947572061","doi":"10.1136/annrheumdis-2019-eular.1176","title":"OP0254 CANAKINUMAB IMPROVES PATIENT-REPORTED OUTCOMES IN PATIENTS WITH RECURRENT FEVER SYNDROMES: RESULTS FROM A PHASE 3 TRIAL (CLUSTER)","year":2019,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital","funders":"EMD Serono; Celgene; Sandwell and West Birmingham Hospitals NHS Trust; Eli Lilly and Company","keywords":"Medicine; Canakinumab; Quality of life (healthcare); Psychosocial; Familial Mediterranean fever; Internal medicine; Pediatrics; Physical therapy; Disease; Psychiatry; Anakinra","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00133434,0.001085029,0.002274505,0.0002653773,0.0003512422,0.0009694577,0.0006415928,0.001167498,0.004401343],"category_scores_gemma":[0.001369796,0.000257702,0.002648117,0.0004190021,0.0006733644,0.0005410897,0.0003796825,0.002536755,0.0006598309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000573296,"about_ca_system_score_gemma":0.0008634387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001203321,"about_ca_topic_score_gemma":0.002896369,"domain_scores_codex":[0.9995901,0.0001556024,0.00002962954,0.00006937474,0.00004037999,0.0001149004],"domain_scores_gemma":[0.9991055,0.0002375711,0.0002211072,0.00008234639,0.00006892522,0.0002845451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8357446,0.0116859,0.007720904,0.002315473,0.008818235,0.0001942923,0.0001224055,0.001291513,0.01158709,0.0002310817,0.006157045,0.1141314],"study_design_scores_gemma":[0.8582439,0.1067167,0.02812849,0.0001396273,0.002866774,0.0001956005,0.00006482084,0.0005107109,0.0009714969,0.0002306384,0.001889202,0.00004201424],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802815,0.01288199,0.0003816179,0.001216289,0.0003393843,0.00101596,0.001590321,0.000118826,0.002173988],"genre_scores_gemma":[0.9832616,0.006626791,0.001240223,0.002084384,0.0005263478,0.001535568,0.002652588,0.00003007651,0.002042492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004401343,"threshold_uncertainty_score":0.01472402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01381585973313702,"score_gpt":0.2686010292850212,"score_spread":0.2547851695518842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}