{"id":"W2947575755","doi":"10.1038/s41419-019-1648-4","title":"Elevated VMP1 expression in acute myeloid leukemia amplifies autophagy and is protective against venetoclax-induced apoptosis","year":2019,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Center, University of Colorado; Universitair Medisch Centrum Groningen; ZonMw; University of Alberta","keywords":"Autophagy; Myeloid leukemia; Haematopoiesis; Chemistry; Cell biology; CD34; Apoptosis; Myeloid; Progenitor cell; Leukemia; Cancer research; Stem cell; Biology; Molecular biology; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006990262,0.0001415696,0.0001833519,0.000180773,0.0001174269,0.0002063459,0.00006808688,0.0001265146,0.001058053],"category_scores_gemma":[0.0001107173,0.00005440442,0.00008830452,0.0001475979,0.0001447556,0.0001055322,0.0001230789,0.0003139216,0.0001420044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002238569,"about_ca_system_score_gemma":0.00009178105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002695837,"about_ca_topic_score_gemma":0.0003077378,"domain_scores_codex":[0.9999404,0.00001127961,0.000004406304,0.00001304622,0.00001362903,0.00001721961],"domain_scores_gemma":[0.99994,0.00001183669,0.0000203489,0.000005306602,0.000005376088,0.00001709539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002618067,0.00001807643,0.0007666195,0.00002697606,0.000003048065,0.0000634869,0.0000124667,0.00003128667,0.9973016,0.00005404119,0.0000314732,0.001429087],"study_design_scores_gemma":[0.00004225876,0.000711827,0.05036413,0.00001273677,0.00002796159,0.001216732,0.00005881451,0.0008783523,0.9434392,0.0001320334,0.003111026,0.000004833788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983516,0.000790646,0.0003844866,0.00002596313,0.00000493068,0.000005035371,0.00008306229,0.00002690095,0.0003273852],"genre_scores_gemma":[0.9989294,0.0002602621,0.0003037307,0.00001069634,0.000004090605,0.000006678726,0.0001314989,0.000003802771,0.0003498058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001058053,"threshold_uncertainty_score":0.003539503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109827070062338,"score_gpt":0.2504490690227823,"score_spread":0.2394663620165485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}