{"id":"W2947622232","doi":"10.1016/j.celrep.2020.02.107","title":"Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Vector Institute; University Health Network; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund; Ontario Institute for Regenerative Medicine; Ontario Institute for Cancer Research; University of Toronto; Marie Curie; Brain Tumour Foundation of Canada; EMBL Australia; European Molecular Biology Laboratory; Ontario Brain Institute; International Rett Syndrome Foundation","keywords":"Rett syndrome; Gene; Key (lock); Ubiquitin; Ribosome; Genetics; Biology; RNA; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001543166,0.0002147249,0.0002273818,0.0003612514,0.0001588194,0.0002786031,0.00008751327,0.0002628348,0.0008823436],"category_scores_gemma":[0.0001941922,0.0001363801,0.0002837345,0.0003263322,0.0002349536,0.0001256925,0.0002091471,0.0002145827,0.0002132148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000267352,"about_ca_system_score_gemma":0.0001945204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001134479,"about_ca_topic_score_gemma":0.002622687,"domain_scores_codex":[0.9998821,0.00000965121,0.00001126839,0.00004521639,0.00003571818,0.00001595453],"domain_scores_gemma":[0.9999089,0.0000203612,0.00003856878,0.000009168361,0.000008315976,0.0000145661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001814475,0.00001235281,0.01379006,0.0000493806,0.0000309893,0.0004043201,0.00005169735,0.0005023873,0.9785832,0.0001769962,0.00008501922,0.006132179],"study_design_scores_gemma":[0.00001776832,0.0002791993,0.4114219,0.00002055899,0.0001039762,0.002565319,0.0001904497,0.003676347,0.578347,0.0006428725,0.002708113,0.00002653224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966649,0.001140734,0.001161745,0.00004516858,0.000007455948,0.000004618153,0.0005762972,0.00005224409,0.0003467053],"genre_scores_gemma":[0.9968362,0.0005519679,0.001350887,0.00006007394,0.000003327902,0.000009296032,0.0005659613,0.00002141094,0.0006008323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001134479,"threshold_uncertainty_score":0.002951801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134327943286446,"score_gpt":0.2375896335705797,"score_spread":0.2241568392419351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}