{"id":"W2947633439","doi":"10.1200/jco.2019.37.15_suppl.5518","title":"A randomized double-blind placebo-controlled phase II trial comparing gemcitabine monotherapy to gemcitabine in combination with adavosertib in women with recurrent, platinum resistant epithelial ovarian cancer: A trial of the Princess Margaret, California, Chicago and Mayo Phase II Consortia.","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; BC Cancer Agency; Princess Margaret Cancer Centre; Ottawa Hospital; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Gemcitabine; Internal medicine; Oncology; Olaparib; BRCA mutation; Ovarian cancer; Cancer; Progression-free survival; Placebo; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004647539,0.0002443923,0.002344173,0.0001623796,0.0000667106,0.00002100077,0.0002910348,0.0002813812,0.00002731794],"category_scores_gemma":[0.001089158,0.0001483071,0.0001875992,0.0002077581,0.0002397784,0.00001390376,0.0001380061,0.000530899,2.276721e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462455,"about_ca_system_score_gemma":0.001890069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000199463,"about_ca_topic_score_gemma":0.002741617,"domain_scores_codex":[0.9957357,0.0007269065,0.002559739,0.0003574036,0.0003021869,0.0003180694],"domain_scores_gemma":[0.9960437,0.0009433658,0.002277265,0.0002689007,0.0002628563,0.0002038638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9814071,0.005336956,0.0008439054,0.00001855687,0.0004503805,0.00001432637,0.0003104933,0.0005559396,0.003836824,0.00008542306,0.0000337342,0.007106329],"study_design_scores_gemma":[0.9124945,0.08205244,0.0003755841,0.0001474929,0.0001593374,0.00000839907,0.00007205361,0.0005469645,0.0005138328,0.00008528375,0.003363084,0.0001809823],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922252,0.0002714084,0.0001488013,0.002127646,0.0007047658,0.004342505,0.0000488539,0.000002106922,0.0001286866],"genre_scores_gemma":[0.997955,0.0005872137,0.000357417,0.0003276014,0.0004277292,0.0002668544,0.000009360592,0.00002325995,0.00004557051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07671548,"threshold_uncertainty_score":0.6047788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04141560706164391,"score_gpt":0.3808206048477158,"score_spread":0.3394049977860719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}