{"id":"W2947642691","doi":"10.1200/jco.2019.37.15_suppl.8502","title":"Initial reporting of NRG-LU001 (NCT02186847), randomized phase II trial of concurrent chemoradiotherapy (CRT) +/- metformin in locally advanced Non-Small Cell Lung Cancer (NSCLC).","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Medicine; Metformin; Carboplatin; Internal medicine; Clinical endpoint; Oncology; Progression-free survival; Lung cancer; Chemoradiotherapy; Chemotherapy; Response Evaluation Criteria in Solid Tumors; non-small cell lung cancer (NSCLC); Paclitaxel; Phases of clinical research; Randomized controlled trial; Cisplatin; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00332099,0.00141398,0.001443633,0.0003347404,0.0003645367,0.0009615302,0.0009774812,0.001609599,0.01390892],"category_scores_gemma":[0.002302663,0.000615944,0.00117634,0.0004837624,0.0005739633,0.0007571627,0.0004206787,0.002532005,0.002385702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00113198,"about_ca_system_score_gemma":0.002114971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001229405,"about_ca_topic_score_gemma":0.006184148,"domain_scores_codex":[0.9991925,0.0004957641,0.00004276801,0.0001020592,0.00007523334,0.000091546],"domain_scores_gemma":[0.9991979,0.0001569936,0.0001897099,0.00006844781,0.0000696022,0.00031736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9527773,0.004589114,0.001485693,0.001071455,0.0009565943,0.00007997504,0.00006192441,0.0004281044,0.004951001,0.000354206,0.008489115,0.02475554],"study_design_scores_gemma":[0.9607227,0.03223579,0.002408133,0.00004815058,0.0003554033,0.00004415976,0.000009964238,0.0002800573,0.0004535884,0.0001496728,0.003281972,0.00001042122],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8479969,0.01237161,0.002768969,0.006719376,0.002246953,0.06057726,0.04239381,0.0008388557,0.02408635],"genre_scores_gemma":[0.8840332,0.004388602,0.005882385,0.005159977,0.001024537,0.04511052,0.03138725,0.0001438977,0.02286956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01390892,"threshold_uncertainty_score":0.04653001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04920128483287982,"score_gpt":0.4557763617730748,"score_spread":0.406575076940195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}