{"id":"W2947644019","doi":"10.1200/jco.2019.37.15_suppl.9022","title":"A phase II study of talazoparib (BMN 673) in patients with homologous recombination repair deficiency (HRRD) positive stage IV squamous cell lung cancer (Lung-MAP Sub-Study, S1400G).","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; PALB2; FANCA; Population; CHEK2; Cancer; Internal medicine; Oncology; Carboplatin; Cancer research; Chemotherapy; Fanconi anemia; DNA repair; Mutation; Germline mutation; Gene; Cisplatin; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001439911,0.001624106,0.001560452,0.0003956627,0.0002352881,0.0007331822,0.0007559014,0.000828441,0.006120715],"category_scores_gemma":[0.0007356692,0.0005913452,0.001248257,0.0003775981,0.0006330814,0.0005193172,0.000351835,0.001651409,0.001265398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008869079,"about_ca_system_score_gemma":0.001517407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001270517,"about_ca_topic_score_gemma":0.003662875,"domain_scores_codex":[0.9996215,0.0002018877,0.0000124004,0.00006249454,0.00003144428,0.0000702085],"domain_scores_gemma":[0.9995685,0.00006730615,0.00007902961,0.00003539169,0.00002798448,0.0002217736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.819585,0.04958602,0.009164907,0.000975348,0.001652634,0.0003121173,0.0002499694,0.002137892,0.03740648,0.0003989211,0.006165671,0.07236506],"study_design_scores_gemma":[0.7085078,0.2766558,0.00931215,0.00002347945,0.0006024222,0.0002096428,0.0000557196,0.0008584389,0.001481093,0.0001992714,0.002074782,0.00001927654],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900302,0.00120661,0.000614969,0.0004411882,0.00009926516,0.003705428,0.001726627,0.00009798741,0.002077694],"genre_scores_gemma":[0.9827715,0.001576396,0.00185608,0.001290307,0.0001572196,0.004293142,0.003739028,0.0000435875,0.004272739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006120715,"threshold_uncertainty_score":0.0204758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03481074056016063,"score_gpt":0.4283296231992632,"score_spread":0.3935188826391025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}