{"id":"W2947706849","doi":"10.1186/s13063-019-3346-z","title":"MEsenchymal StEm cells for Multiple Sclerosis (MESEMS): a randomized, double blind, cross-over phase I/II clinical trial with autologous mesenchymal stem cells for the therapy of multiple sclerosis","year":2019,"lang":"en","type":"article","venue":"Trials","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Sanofi Genzyme; Paracelsus Medizinische Privatuniversität; Multiple Sclerosis International Federation; AFM-Téléthon; Imperial College London; European Committee for Treatment and Research in Multiple Sclerosis; Multiple Sclerosis Society; Scleroseforeningen; Toyota Foundation; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; Teva Pharmaceutical Industries; National Institute for Health and Care Research; Sanofi; Danmarks Frivillige Bloddonorer; Fondazione Italiana Sclerosi Multipla; Biogen","keywords":"Mesenchymal stem cell; Medicine; Multiple sclerosis; Stem cell; Stem-cell therapy; Clinical trial; Pathology; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003342378,0.002660226,0.003771882,0.001189921,0.0006895507,0.001163836,0.001030331,0.002813687,0.008456567],"category_scores_gemma":[0.002000167,0.000736171,0.001389374,0.0007087448,0.001779223,0.001207734,0.0006666346,0.001927716,0.001251423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006420654,"about_ca_system_score_gemma":0.002047299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004294106,"about_ca_topic_score_gemma":0.0009389821,"domain_scores_codex":[0.9986497,0.0007343288,0.00009657104,0.0002243702,0.0001472006,0.0001479685],"domain_scores_gemma":[0.9989185,0.0002278373,0.0002857873,0.00009356339,0.0001205344,0.000353802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9708866,0.01392083,0.0002867726,0.0008641603,0.0003738886,0.00003502716,0.00005272017,0.000228932,0.003937336,0.000225619,0.0005407207,0.008647498],"study_design_scores_gemma":[0.9475329,0.05100752,0.0003873611,0.00002171634,0.0001128474,0.00001156514,0.00000887273,0.0001155013,0.0002646649,0.00007245645,0.0004581794,0.000006468008],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9346749,0.006689043,0.001785494,0.001817001,0.001280498,0.04712623,0.00240515,0.0003435872,0.003878113],"genre_scores_gemma":[0.8848618,0.005667407,0.01004856,0.003021525,0.001678259,0.08178141,0.002664134,0.00006710738,0.01020981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008456567,"threshold_uncertainty_score":0.02829003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.43771613823638,"score_gpt":0.462930422822696,"score_spread":0.02521428458631597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}