{"id":"W2947748629","doi":"10.1016/j.jaad.2019.05.063","title":"A randomized phase 3b/4 study to evaluate concomitant use of topical ivermectin 1% cream and doxycycline 40-mg modified-release capsules, versus topical ivermectin 1% cream and placebo in the treatment of severe rosacea","year":2019,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Acne and Rosacea Treatments and Effects","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health; University of Toronto","funders":"Sanofi Genzyme; Almirall; LEO Pharma; Galderma; Bayer HealthCare; Allergan; Eli Lilly and Company; Regeneron Pharmaceuticals; Biofrontera; Celgene; Sanofi","keywords":"Ivermectin; Medicine; Doxycycline; Concomitant; Placebo; Dermatology; Randomized controlled trial; Pharmacology; Surgery; Antibiotics; Veterinary medicine; Microbiology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004115824,0.0002417618,0.001896457,0.0001664328,0.00005062665,0.000007824962,0.0001670612,0.00009532929,0.00001414147],"category_scores_gemma":[0.000408887,0.0001182808,0.0002684928,0.000202788,0.0004941354,0.00006659712,0.00006967279,0.0003232934,0.000001191206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007146242,"about_ca_system_score_gemma":0.0000921956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003251905,"about_ca_topic_score_gemma":0.00002066941,"domain_scores_codex":[0.9972145,0.001086869,0.0009020278,0.0002148233,0.0003416273,0.000240129],"domain_scores_gemma":[0.9967176,0.001919275,0.0009362472,0.0002070929,0.00006940876,0.0001504164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7386355,0.01700804,0.2034875,0.0002044538,0.003809546,0.0005917844,0.01538463,0.0003892125,0.007892341,0.0002014881,0.0007488368,0.01164676],"study_design_scores_gemma":[0.7627867,0.03088522,0.1783036,0.0003547176,0.004347162,0.003600371,0.009190011,0.002182615,0.007071369,0.0001388971,0.0008008108,0.0003384861],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937226,0.0004929322,0.000009861461,0.003971431,0.0001129688,0.00161263,0.00001835726,0.000003376372,0.00005581709],"genre_scores_gemma":[0.9986676,0.0006583395,0.0002041761,0.000335253,0.00005000363,0.00001386293,0.000001128248,0.00001147305,0.00005816446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02518381,"threshold_uncertainty_score":0.4823352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03789430203727268,"score_gpt":0.3605410744082574,"score_spread":0.3226467723709847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}