{"id":"W2947748629","doi":"10.1016/j.jaad.2019.05.063","title":"A randomized phase 3b/4 study to evaluate concomitant use of topical ivermectin 1% cream and doxycycline 40-mg modified-release capsules, versus topical ivermectin 1% cream and placebo in the treatment of severe rosacea","year":2019,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Acne and Rosacea Treatments and Effects","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health; University of Toronto","funders":"Sanofi Genzyme; Almirall; LEO Pharma; Galderma; Bayer HealthCare; Allergan; Eli Lilly and Company; Regeneron Pharmaceuticals; Biofrontera; Celgene; Sanofi","keywords":"Ivermectin; Medicine; Doxycycline; Concomitant; Placebo; Dermatology; Randomized controlled trial; Pharmacology; Surgery; Antibiotics; Veterinary medicine; Microbiology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004705335,0.003078469,0.005370428,0.0009866628,0.0008138349,0.00131716,0.002047882,0.003030996,0.01362699],"category_scores_gemma":[0.003629471,0.001621088,0.002000415,0.0007887363,0.002412616,0.001640406,0.0006661564,0.003596202,0.002402609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001071785,"about_ca_system_score_gemma":0.002483927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009351483,"about_ca_topic_score_gemma":0.001995762,"domain_scores_codex":[0.9980464,0.001135109,0.00008549671,0.0003441925,0.0001454766,0.0002432506],"domain_scores_gemma":[0.9974427,0.0006630996,0.0005412762,0.0002922772,0.000248733,0.0008119144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9753701,0.0154421,0.000269327,0.0002729176,0.000299999,0.00002356554,0.00002555581,0.0001265964,0.002483034,0.00005204156,0.0003728558,0.005261887],"study_design_scores_gemma":[0.9290808,0.06980124,0.000398746,0.000008647798,0.00009772497,0.00001144815,0.000006999394,0.0001312669,0.0001894215,0.00005618706,0.0002114242,0.000006162487],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9457686,0.003724823,0.002699335,0.001174883,0.001483757,0.03889231,0.002833598,0.0004242322,0.002998593],"genre_scores_gemma":[0.9208448,0.002814886,0.01098603,0.002649161,0.001381081,0.05026505,0.002676919,0.0001166603,0.008265514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01362699,"threshold_uncertainty_score":0.04558682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03789430203727268,"score_gpt":0.3605410744082574,"score_spread":0.3226467723709847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}