{"id":"W2947749725","doi":"10.1200/jco.2019.37.15_suppl.tps2646","title":"A phase I/Ib multicenter study to evaluate the humanized anti-CD73 antibody, CPI-006, as a single agent, in combination with CPI-444, and in combination with pembrolizumab in adult patients with advanced cancers.","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Internal medicine; Pembrolizumab; Oncology; Tolerability; Immunotherapy; Cancer; Adverse effect","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001662309,0.001838058,0.001633936,0.0004431086,0.0005675239,0.001189368,0.0008584743,0.001292798,0.007152213],"category_scores_gemma":[0.0007132516,0.0007270894,0.001046418,0.0004399954,0.0009325547,0.001104453,0.0003682604,0.00321364,0.001639982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001196744,"about_ca_system_score_gemma":0.002844811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001443996,"about_ca_topic_score_gemma":0.003185177,"domain_scores_codex":[0.9996434,0.0001417792,0.00001534803,0.00007420122,0.00003363986,0.00009161999],"domain_scores_gemma":[0.9993224,0.00005196583,0.0001166976,0.00004185315,0.00005828889,0.0004088391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7127755,0.1343707,0.006427456,0.0008327576,0.001260007,0.000267177,0.0002885713,0.002146529,0.04710767,0.0004482355,0.009393045,0.08468231],"study_design_scores_gemma":[0.5272357,0.4557628,0.007660073,0.00004000075,0.0004001581,0.0002547725,0.00007637347,0.0007359055,0.002533913,0.0002484757,0.005029752,0.00002214931],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729018,0.003161356,0.001385891,0.00129179,0.000314102,0.0127838,0.003954498,0.0002170931,0.003989807],"genre_scores_gemma":[0.9615846,0.003217309,0.00483423,0.003072495,0.0004090362,0.01386337,0.005414729,0.00006924942,0.007535113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007152213,"threshold_uncertainty_score":0.0239265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02856637242001332,"score_gpt":0.4017550666596621,"score_spread":0.3731886942396488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}