{"id":"W2947784516","doi":"10.1080/09537104.2019.1624709","title":"Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP)","year":2019,"lang":"en","type":"article","venue":"Platelets","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Health Canada; Canadian Blood Services; Amgen","keywords":"Thrombopoietin; Eltrombopag; Platelet; Romiplostim; Medicine; Thrombopoietin receptor; Autoantibody; Autoimmune thrombocytopenia; Immunology; Internal medicine; Antibody; Immune system; Megakaryocyte; Endocrinology; Immune thrombocytopenia; Haematopoiesis; Biology; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001451148,0.0005410015,0.001283762,0.0002003926,0.0001290301,0.00008966759,0.0001441041,0.0002438234,0.001197707],"category_scores_gemma":[0.00001619862,0.0004023107,0.00009911693,0.000312649,0.0001655084,0.000238946,0.00004513317,0.0002660392,0.001148899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001794242,"about_ca_system_score_gemma":0.0001639522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003301665,"about_ca_topic_score_gemma":0.00004493742,"domain_scores_codex":[0.997736,0.00005222371,0.0004680257,0.0007390828,0.0003595925,0.0006451191],"domain_scores_gemma":[0.9990565,0.0001146569,0.0001828827,0.0003967443,0.00006647874,0.0001827344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004445693,0.007167994,0.1421424,0.0008070005,0.003768174,0.01232392,0.005268027,0.00006152845,0.7563809,0.0003070716,0.004510873,0.06281641],"study_design_scores_gemma":[0.04349065,0.00667999,0.4084188,0.001748874,0.0004563449,0.003660966,0.001086275,0.0002712511,0.422581,0.0001310926,0.1091791,0.002295587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856155,0.002350325,0.000002184516,0.0003910069,0.0002967968,0.001260692,0.000131663,0.000105011,0.009846837],"genre_scores_gemma":[0.9940366,0.002635592,0.0004710082,0.0001365337,0.00005648554,0.00003430546,0.0004656961,0.00008242601,0.002081424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3337999,"threshold_uncertainty_score":0.9998429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01800325880614058,"score_gpt":0.2829486883701441,"score_spread":0.2649454295640035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}