{"id":"W2947837169","doi":"10.1200/jco.2020.38.6_suppl.tps383","title":"PROTEUS: A randomized, double-blind, placebo (PBO)-controlled, phase III trial of apalutamide (APA) plus androgen deprivation therapy (ADT) versus PBO plus ADT prior to radical prostatectomy (RP) in patients with localized high-risk or locally advanced prostate cancer (PC).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Janssen Research and Development","keywords":"Medicine; Androgen deprivation therapy; Prostatectomy; Urology; Prostate cancer; Placebo; Internal medicine; Randomization; Antiandrogen; Biopsy; Prostate-specific antigen; Randomized controlled trial; Oncology; Gastroenterology; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001357027,0.002479147,0.002980214,0.0006419004,0.0006067725,0.001444353,0.00121761,0.002074591,0.008804856],"category_scores_gemma":[0.001649248,0.000846379,0.001795617,0.0004775305,0.001539099,0.001225366,0.0006029747,0.003459775,0.001775417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007476072,"about_ca_system_score_gemma":0.001897652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009940478,"about_ca_topic_score_gemma":0.002816994,"domain_scores_codex":[0.9995216,0.0002326219,0.0000245826,0.00009767811,0.00003948344,0.00008412448],"domain_scores_gemma":[0.9993244,0.0001271468,0.0001761042,0.00004812278,0.00005143992,0.000272774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.979715,0.007050971,0.0001793661,0.0008121381,0.0005234944,0.00002094033,0.00003152517,0.0001583189,0.002518603,0.0001424642,0.0007730263,0.008074115],"study_design_scores_gemma":[0.9704041,0.02821892,0.0003279395,0.00002736315,0.000149194,0.00001528637,0.00001170356,0.0001386252,0.0001659221,0.000132229,0.0004009335,0.000007726681],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611496,0.008063651,0.001711437,0.002072985,0.002194133,0.01643637,0.002958743,0.0005797307,0.004833302],"genre_scores_gemma":[0.9530669,0.005276241,0.00427005,0.002650751,0.0008982448,0.02319424,0.001961505,0.00007681996,0.008605283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008804856,"threshold_uncertainty_score":0.02945518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08701395422269277,"score_gpt":0.4446149494255303,"score_spread":0.3576009952028376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}